Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pansy, K; Uhl, B; Krstic, J; Szmyra, M; Fechter, K; Santiso, A; Thüminger, L; Greinix, H; Kargl, J; Prochazka, K; Feichtinger, J; Deutsch, AJ.
Immune Regulatory Processes of the Tumor Microenvironment under Malignant Conditions.
Int J Mol Sci. 2021; 22(24):
Doi: 10.3390/ijms222413311
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- Führende Autor*innen der Med Uni Graz
- Deutsch Alexander
- Pansy Katrin
- Co-Autor*innen der Med Uni Graz
- Fechter Karoline
- Feichtinger Julia
- Greinix Hildegard
- Kargl Julia
- Krstic Jelena
- Santiso Sanchez Ana Luisa
- Szmyra-Polomka Marta Malwina
- Uhl Barbara
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- Abstract:
- The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and metastasis. Since immune cells represent a large fraction of the TME, they play a key role in mediating pro- and anti-tumor immune responses. Immune escape, which suppresses anti-tumor immunity, enables tumor cells to maintain their proliferation and growth. Numerous mechanisms, which have been intensively studied in recent years, are involved in this process and based on these findings, novel immunotherapies have been successfully developed. Here, we review the composition of the TME and the mechanisms by which immune evasive processes are regulated. In detail, we describe membrane-bound and soluble factors, their regulation, and their impact on immune cell activation in the TME. Furthermore, we give an overview of the tumor/antigen presentation and how it is influenced under malignant conditions. Finally, we summarize novel TME-targeting agents, which are already in clinical trials for different tumor entities.
- Find related publications in this database (Keywords)
- tumor microenvironment
- anti-tumor immune responses
- immune evasion
- immune checkpoint
- cytokines
- metabolism
- antigen presentation
- TME targeting therapy