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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hassler, E; Almer, G; Reishofer, G; Marsche, G; Mangge, H; Deutschmann, H; Herrmann, M; Leber, S; Gunzer, F; Renner, W.
Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length.
Antioxidants (Basel). 2021; 10(12):
Doi: 10.3390/antiox10121908
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- Leading authors Med Uni Graz
- Almer Gunter
- Hassler Eva Maria
- Reishofer Gernot
- Co-authors Med Uni Graz
- Deutschmann Hannes
- Gunzer Felix
- Herrmann Markus
- Leber Stefan
- Mangge Harald
- Marsche Gunther
- Renner Wilfried
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- Abstract:
- Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which are promoted by an imbalance among reactive oxygen species (ROS) and antioxidants. In this cross-sectional study, we investigated the relationship between telomeres and oxidative stress. The serum leucocyte telomer length (LTL), serum total antioxidant capacity (TAC) and the total serum lipid panel of 180 healthy athletic volunteers (90 males, 90 females) were measured Additionally, a questionnaire about sports behaviour and the type of training was completed. We observed a positive significant relation between serum LTL and TAC in the male group (cc = 3.4/p = 0.001) but not in females. There was no statistically significant correlation between age and physical activity and LTL in both groups. This is the first cross sectional study demonstrating an association between total serum TAC and LTL in healthy males, but interestingly, not in the females. Nevertheless, these results should be interpreted as preliminary, and further studies in independent cohorts are needed to investigate the sex-specific effects of oxidative stress on telomere length and telomerase activity.
- Find related publications in this database (Keywords)
- leucocyte telomere length
- telomere shortening
- oxidative stress
- telomerase
- total antioxidative capacity
- lifestyle changes