Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Heilbronner, U; Streit, F; Vogl, T; Senner, F; Schaupp, SK; Reich-Erkelenz, D; Papiol, S; Oraki, Kohshour, M; Klöhn-Saghatolislam, F; Kalman, JL; Heilbronner, M; Gade, K; Comes, AL; Budde, M; Andlauer, TFM; Anderson-Schmidt, H; Adorjan, K; Stürmer, T; Loerbroks, A; Amelang, M; Poisel, E; Foo, J; Heilmann-Heimbach, S; Forstner, AJ; Degenhardt, F; Zimmermann, J; Wiltfang, J; von, Hagen, M; Spitzer, C; Schmauss, M; Reininghaus, E; Reimer, J; Konrad, C; Juckel, G; Lang, FU; Jäger, M; Figge, C; Fallgatter, AJ; Dietrich, DE; Dannlowski, U; Baune, BT; Arolt, V; Anghelescu, IG; Nöthen, MM; Witt, SH; Andreassen, OA; Chen, CH; Falkai, P; Rietschel, M; Schulze, TG; Schulte, EC.
Interplay between the genetics of personality traits, severe psychiatric disorders and COVID-19 host genetics in the susceptibility to SARS-CoV-2 infection.
BJPSYCH OPEN. 2021; 7(6): e188
Doi: 10.1192/bjo.2021.1030
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- Co-Autor*innen der Med Uni Graz
- Reininghaus Eva
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- Abstract:
- Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, with its impact on our way of life, is affecting our experiences and mental health. Notably, individuals with mental disorders have been reported to have a higher risk of contracting SARS-CoV-2. Personality traits could represent an important determinant of preventative health behaviour and, therefore, the risk of contracting the virus. Aims: We examined overlapping genetic underpinnings between major psychiatric disorders, personality traits and susceptibility to SARS-CoV-2 infection. Method: Linkage disequilibrium score regression was used to explore the genetic correlations of coronavirus disease 2019 (COVID-19) susceptibility with psychiatric disorders and personality traits based on data from the largest available respective genome-wide association studies (GWAS). In two cohorts (the PsyCourse (n = 1346) and the HeiDE (n = 3266) study), polygenic risk scores were used to analyse if a genetic association between, psychiatric disorders, personality traits and COVID-19 susceptibility exists in individual-level data. Results: We observed no significant genetic correlations of COVID-19 susceptibility with psychiatric disorders. For personality traits, there was a significant genetic correlation for COVID-19 susceptibility with extraversion (P = 1.47 × 10-5; genetic correlation 0.284). Yet, this was not reflected in individual-level data from the PsyCourse and HeiDE studies. Conclusions: We identified no significant correlation between genetic risk factors for severe psychiatric disorders and genetic risk for COVID-19 susceptibility. Among the personality traits, extraversion showed evidence for a positive genetic association with COVID-19 susceptibility, in one but not in another setting. Overall, these findings highlight a complex contribution of genetic and non-genetic components in the interaction between COVID-19 susceptibility and personality traits or mental disorders.
- Find related publications in this database (Keywords)
- COVID-19
- extraversion
- severe mental disorders
- personality traits
- genetics