Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Houschyar, KS; Borrelli, MR; Tapking, C; Rein, S; Popp, D; Puladi, B; Wallner, C; Schulz, T; Maan, ZN; Duscher, D; Kluwig, D; Yazdi, AS; Philipp-Dormston, WG.
Wnt signaling and Hedgehog expression in basal cell carcinoma
EUR J PLAST SURG. 2021;
Doi: 10.1007/s00238-021-01920-3
Web of Science
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- Co-Autor*innen der Med Uni Graz
- Popp Daniel
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- Abstract:
- Basal cell carcinoma (BCC) is the most common skin cancer worldwide, and its incidence is increasing due to the aging population and the cumulative effects of widespread sun exposure. The Wnt gene family is involved in cell growth regulation, differentiation, and organogenesis, and not surprisingly, Wnt genes have been linked to oncogenesis. Specifically, beta-catenin, a key signaling regulator of the Wnt pathway, is involved in the genesis of numerous human cancers including BCCs. Dysregulation of the patched/hedgehog intracellular signaling pathway, other important pathways regulating cell growth and regulation, has also been linked to BCCs. In this review, we outline the key mechanisms of the Wnt and patched/hedgehog intracellular signaling pathways and their involvement in the development, homeostasis, and progression of BCCs.
- Find related publications in this database (Keywords)
- Stem cells
- Carcinoma
- Wnt signaling
- Basal cell carcinoma
- beta-catenin