Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gabriel, M; Kruger, R; Shams-Mafi, F; Hermann, B; Zabihian, B; Schmetterer, L; Drexler, W; Binder, S; Esmaeelpour, M.
Mapping Retinal and Choroidal Thickness in Unilateral Nongranulomatous Acute Anterior Uveitis Using Three-Dimensional 1060-nm Optical Coherence Tomography.
Invest Ophthalmol Vis Sci. 2017; 58(11): 4778-4783.
Doi: 10.1167/iovs.17-22265
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Gabriel Maximilian
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- Abstract:
- Purpose: To analyze retinal thickness (RT) and choroidal thickness (ChT) changes in patients with unilateral nongranulomatous acute anterior uveitis (AAU) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT). Methods: Retinal and choroidal thickness maps were statistically analyzed for 24 patients with newly diagnosed unilateral AAU before therapy. A total of 17 patients were followed until resolution of inflammatory activity (twice in the first week, then weekly). Resolution occurred in all subjects within 6 weeks after the initial diagnosis. After resolution, thickness maps were again generated. All patients were imaged by high-speed spectral-domain (SD) 3D 1060-nm OCT over a 10 × 10-mm field of view. The spatial distribution of retinal and choroidal thickness was mapped and analyzed using the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. Results: The choroid was significantly thicker in eyes affected by AAU than in fellow eyes before therapy with a mean thickness difference of 37 ± 11.44 μm (mean ± SD, Bonferroni correction, α = 0.0125). Following therapy, ChT significantly decreased with a mean change of 24 ± 6.9 μm (mean ± SD, Bonferroni correction, α = 0.0125). There was no significant difference in RT between AAU and fellow eyes before therapy or in AAU eyes before and after therapy. Conclusions: Eyes affected by AAU demonstrate an increase in ChT before and a subsequent decrease after therapy while retinal thickness seems unaltered by disease and therapy. ChT might be a useful biomarker in monitoring posterior involvement and response to therapy in patients with AAU.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease - administration & dosage
- Adult - administration & dosage
- Aged - administration & dosage
- Case-Control Studies - administration & dosage
- Choroid - diagnostic imaging, pathology
- Female - administration & dosage
- Humans - administration & dosage
- Imaging, Three-Dimensional - methods
- Male - administration & dosage
- Middle Aged - administration & dosage
- Retina - diagnostic imaging, pathology
- Tomography, Optical Coherence - methods
- Uveitis, Anterior - diagnostic imaging, pathology
- Find related publications in this database (Keywords)
- choroidal thickness
- acute anterior uveitis
- optical coherence tomography