Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Grossmann, T; Darnhofer, B; Birner-Gruenberger, R; Kirsch, A; Gugatschka, M.
Descriptive proteomics of paired human vocal fold and buccal mucosa tissue.
Proteomics Clin Appl. 2022; 16(2):e2100050
Doi: 10.1002/prca.202100050
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- Führende Autor*innen der Med Uni Graz
- Darnhofer Barbara
- Grossmann Tanja
- Kirsch Andrijana
- Co-Autor*innen der Med Uni Graz
- Birner-Grünberger Ruth
- Gugatschka Markus
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- Abstract:
- The vast majority of voice disorders is associated with changes of the unique, but delicate, human vocal fold mucosa. The ability to develop new effective treatment methods is significantly limited by the physical inaccessibility and the extremely rare occasions under which healthy tissue biopsies can be obtained. Therefore, the interest in laryngological research has shifted to human oral (buccal) mucosa, a similar and more easily available tissue. The harvesting process is less invasive and accompanied with faster healing and less scarring, compared to vocal fold mucosa. Here we report a descriptive proteomic comparison of paired human buccal and vocal fold mucosa by high-resolution mass spectrometry (CID-MS/MS). Our study identified a total of 1575 proteins detected within both tissues that are highly consistent in several crucial biological processes, cellular components, and molecular functions. Hence, our proteomic analysis will provide a fundamental resource for the laryngological research community.
- Find related publications in this database (Keywords)
- descriptive proteomics
- human tissue
- oral buccal mucosa
- vocal folds