Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Krappinger, JC; Bonstingl, L; Pansy, K; Sallinger, K; Wreglesworth, NI; Grinninger, L; Deutsch, A; El-Heliebi, A; Kroneis, T; Mcfarlane, RJ; Sensen, CW; Feichtinger, J.
Non-coding Natural Antisense Transcripts: Analysis and Application.
J Biotechnol. 2021; 340:75-101
Doi: 10.1016/j.jbiotec.2021.08.005
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Feichtinger Julia
- Krappinger Julian Christopher
- Co-Autor*innen der Med Uni Graz
- Bonstingl Lilli
- Deutsch Alexander
- El-Heliebi Amin
- Grinninger Lukas
- Kroneis Thomas
- Pansy Katrin
- Sallinger Katja
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- Abstract:
- Non-coding natural antisense transcripts (ncNATs) are regulatory RNA molecules that are overlapping with as well as complementary to other transcripts. These transcripts are implicated in a broad variety of biological and pathological processes, including tumorigenesis and oncogenic progression. With this complex field still in its infancy, annotations, expression profiling and functional characterisations of ncNATs are far less comprehensive than those for protein-coding genes, pointing out substantial gaps in the analysis and characterisation of these regulatory transcripts. In this review, we discuss ncNATs from an analysis perspective, in particular regarding the use of high-throughput sequencing strategies, such as RNA-sequencing, and summarize the unique challenges of investigating the antisense transcriptome. Finally, we elaborate on their potential as biomarkers and future targets for treatment, focusing on cancer.
- Find related publications in this database (using NLM MeSH Indexing)
- Base Sequence - administration & dosage
- High-Throughput Nucleotide Sequencing - administration & dosage
- RNA, Antisense - genetics
- Sequence Analysis, RNA - administration & dosage
- Transcriptome - genetics
- Find related publications in this database (Keywords)
- natural antisense transcripts
- biomarkers
- strand-specific RNA-seq
- long non-coding RNAs
- liquid biopsy