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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Nogales, FF; Buriticá, C; Regauer, S; González, T.
Mucinous carcinoid as an unusual manifestation of endodermal differentiation in ovarian yolk sac tumors.
Am J Surg Pathol. 2005; 29(9):1247-1251
Doi: 10.1097/01.pas.0000161533.39478.a7
(- Case Report)
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- Co-authors Med Uni Graz
- Regauer Sigrid
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- Abstract:
- We present, for the first time, two yolk sac tumors (YST) in women 37 and 18 years of age, one with a typical parietovisceral pattern and the other with a glandular pattern, which were associated with extensive areas of mucinous carcinoid (MC). The tumor in the first case had numerous nodules of tubulopapillary YST that merged with well-differentiated MC. This patient responded well to chemotherapy. The tumor in the second case consisted of an AFP-positive glandular YST, with a glandulopapillary pattern closely resembling fetal lung type adenocarcinoma, coexisting with an AFP-negative, cytokeratin 20-positive, atypical MC; transitional areas between the two components were also seen. In the material from the recurrences and metastases; however, no YST was present, the atypical MC having become the predominant component including areas that had become carcinomatous. There was a poor response to various chemotherapeutic regimens. AFP levels became negative during the course of disease paralleling the disappearance of the YST component and the overgrowth of an increasingly anaplastic MC. The patient died 1 year after diagnosis. We think that, in these cases, MC represented an unusual form of endodermal differentiation of the YST. It is important to differentiate the yolk sac and carcinoid components due to their different responses to chemotherapy and to evaluate the possibility of mucinous carcinoid developing into a highly aggressive carcinoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Antineoplastic Agents - therapeutic use
- Carcinoid Tumor - drug therapy
- Endodermal Sinus Tumor - drug therapy
- Female - drug therapy
- Humans - drug therapy
- Immunohistochemistry - drug therapy
- Neoplasm Metastasis - pathology
- Neoplasm Recurrence, Local - drug therapy
- Ovarian Neoplasms - drug therapy
- Prognosis - drug therapy
- Treatment Outcome - drug therapy
- alpha-Fetoproteins - metabolism
- Find related publications in this database (Keywords)
- yolk sac tumor
- adenocarcinoid
- mucinous carcinoid
- endoderm