Medizinische Universität Graz - Research portal
Selected Publication:
Urlesberger, B; Zobel, G; Dacar, D; Rödl, S; Trafojer, U; Trantina, A; Knez, J.
Partial liquid ventilation combined with kinetic therapy in acute respiratory failure in piglets.
Intensive Care Med. 1999; 25(5):496-502
Doi: 10.1007/s001340050887
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Urlesberger Berndt
- Co-authors Med Uni Graz
- Dacar Drago
- Knez Igor
- Roedl Siegfried
- Yates Ameli
- Zobel Gerfried
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- Abstract:
- OBJECTIVE: To investigate the effect of the combination of kinetic therapy (KT) with partial liquid ventilation (PLV) on gas exchange, lung mechanics and hemodynamics in acute lung injury (ALI). DESIGN: Prospective, randomized, controlled pilot study. SETTING: University research laboratory. SUBJECTS: Eleven piglets weighing 8.3+/-0.9 kg. INTERVENTION: ALI was induced by the infusion of oleic acid (0.08 ml/kg) and repeated lung lavages with 0.9% NaCl (20 ml kg(-1)). Thereafter the animals were randomly assigned either for PLV or a combination of PLV with KT (PLV/KT). The dose of perfluorocarbon administered was 30 ml/kg, evaporative losses were substituted with 5 ml/kg per h. MEASUREMENTS AND MAIN RESULTS: Airway pressures, tidal volumes, dynamic compliance (Cdyn), expiratory airway resistance and arterial blood gases were measured. Hemodynamic monitoring included right atrial, mean pulmonary artery, pulmonary capillary wedge and mean systemic arterial pressures, and continuous flow recording of the pulmonary artery. In both groups the induction of ALI significantly reduced PaO2/FIO2 Cdyn and cardiac output, and significantly increased pulmonary artery pressure. After the initiation of PLV there was a significant increase of PaO2/FIO2, and Cdyn, and a significant decrease of pulmonary artery pressure in both groups. Except the PaCO2, which showed significantly lower values in the PLV/KT group, no variables showed any differences between the two groups. CONCLUSION: The additional use of KT did not show beneficial effects on oxygenation and lung mechanics during PLV. However, at constant minute ventilation PaCO2 levels were significantly lower during PLV/KT, indicating some positive influence on the ventilation/perfusion distribution within the lung. Extreme body positions during PLV/KT did not show any significant hemodynamic side effects.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Analysis of Variance -
- Animals -
- Disease Models, Animal -
- Fluorocarbons - therapeutic use
- Hemodynamics - therapeutic use
- Intubation, Intratracheal - therapeutic use
- Physical Therapy Modalities - methods
- Pulmonary Gas Exchange - methods
- Respiration, Artificial - methods
- Respiratory Insufficiency - therapy
- Respiratory Mechanics - therapy
- Swine - therapy
- Find related publications in this database (Keywords)
- Acute Lung Injury
- Partial Liquid Ventilation
- Kinetic Therapy
- Lung Function
- Hemodynamic Monitoring