Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ahyai, SA; Graefen, M; Steuber, T; Haese, A; Schlomm, T; Walz, J; Köllermann, J; Briganti, A; Zacharias, M; Friedrich, MG; Karakiewicz, PI; Montorsi, F; Huland, H; Chun, FK.
Contemporary prostate cancer prevalence among T1c biopsy-referred men with a prostate-specific antigen level < or = 4.0 ng per milliliter.
Eur Urol. 2008; 53(4):750-7
Doi: 10.1016/j.eururo.2007.10.017
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Ahyai Sascha
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- Abstract:
- OBJECTIVE: To investigate the prostate cancer (PCa) prevalence and risk factors of men with prostate-specific antigen (PSA) level< or =4.0 ng/ml and an unsuspicious digital rectal examination (DRE) in a large biopsy referral cohort. MATERIALS AND METHODS: Between 1997 and 2005, 855 men underwent initial transrectal ultrasound (TRUS)-guided prostate biopsy at the University Hospital Hamburg-Eppendorf. Patients with any previous surgical or medical treatment were excluded from analyses. Logistic regression analyses were performed to determine risk factors of PCa at biopsy and high-grade PCa defined as biopsy Gleason sum> or =7. RESULTS: Overall PCa detection rate was 23.1%. The majority had a biopsy Gleason sum of 6 (79.5%) and 20.5% had a biopsy Gleason sum> or =7. Total PSA (tPSA) and percentage of free PSA (%fPSA) were statistically significantly different in men with and without PCa (all p<0.001). In tPSA strata < or = 0.5, 0.6-1.0, 1.1-2.0, 2.1-3.0, and 3.1-4.0 ng/ml, PCa prevalence was 4.0%, 10.6%, 14.8%, 24.5%, and 32.1%, respectively. In logistic regression analyses addressing PCa and Gleason sum > or = 7 at biopsy, %fPSA and prostate volume represented independent and most informative risk factors. CONCLUSION: Our data demonstrate that a substantial percentage (23.1%) of men with a PSA< or =4.0 ng/ml and an unsuspicious DRE in a biopsy referral population harbor PCa, with 20.5% being high grade. Low %fPSA and low prostate volume represent important parameters in PCa and in high grade disease detection at biopsy, respectively.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Aged, 80 and over - administration & dosage
- Area Under Curve - administration & dosage
- Biopsy - administration & dosage
- Chi-Square Distribution - administration & dosage
- Germany - epidemiology
- Humans - administration & dosage
- Logistic Models - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Physical Examination - administration & dosage
- Predictive Value of Tests - administration & dosage
- Prevalence - administration & dosage
- Prostate-Specific Antigen - blood
- Prostatic Neoplasms - blood, epidemiology, pathology
- Risk Factors - administration & dosage
- Ultrasonography, Interventional - administration & dosage
- Find related publications in this database (Keywords)
- prostate cancer prevalence
- referral cohort
- early detection
- low PSA
- %fPSA
- prostate volume