Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Chun, FK; Suardi, N; Capitanio, U; Jeldres, C; Ahyai, S; Graefen, M; Haese, A; Steuber, T; Erbersdobler, A; Montorsi, F; Huland, H; Karakiewicz, PI.
Assessment of pathological prostate cancer characteristics in men with favorable biopsy features on predominantly sextant biopsy.
Eur Urol. 2009; 55(3):617-28-6
Doi: 10.1016/j.eururo.2008.04.099
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ahyai Sascha
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND: The rate of insignificant prostate cancer (IPCa) is increasing. OBJECTIVES: To examine three end points in patients with a single, positive core and no high-grade prostate cancer (PCa) at biopsy, namely (1) rate of clinical IPCa at radical prostatectomy (RP), defined as organ-confined PCa with a Gleason score of 6 or lower and tumor volume<0.5 cc; (2) rate of pathologically unfavorable PCa at RP (Gleason 7-10 or non-organ-confined disease); and (3) ability to predict either insignificant or unfavorable PCa at RP. DESIGN, SETTING, AND PARTICIPANTS: Retrospective analysis of 209 men with one positive biopsy core showing Gleason 6 or lower. MEASUREMENTS: : Detailed clinical and RP data were used in multivariable logistic regression models. Their bias-corrected accuracy estimates were quantified using the area under the curve (AUC) method. RESULTS AND LIMITATIONS: At RP, IPCa was present in 28 patients (13.4%) and pathologically unfavorable PCa, defined as Gleason 7 or higher or non-organ-confined PCa, was reported in 70 (33.5%) of 209 men; when Gleason 8 or higher or non-organ-confined PCa was considered, the proportion fell to 11%. Our multivariable models predicting different categories of pathologically unfavorable PCa at RP had an accuracy rate between 56% and 68% for predicting IPCa at RP versus 65.1% to 66.1% and 61.7% for the IPCa nomograms of Kattan et al and Nakanishi et al, respectively. Our data are not applicable to screening because they originate from a referral population. CONCLUSIONS: Despite highly favorable biopsy features, between 11% and 33% of men had unfavorable PCa at RP and only a minority (13.4%) had pathologically confirmed IPCa. Neither clinically insignificant nor pathologically unfavorable features could be predicted with sufficient accuracy for clinical decision making.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Biopsy, Needle - methods
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Predictive Value of Tests - administration & dosage
- Prostatic Neoplasms - pathology
- Retrospective Studies - administration & dosage
- Find related publications in this database (Keywords)
- Prostate cancer
- Minimal disease
- Radical prostatectomy