Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tilki, D; Preisser, F; Tennstedt, P; Tober, P; Mandel, P; Schlomm, T; Steuber, T; Huland, H; Schwarz, R; Petersen, C; Graefen, M; Ahyai, S.
Adjuvant radiation therapy is associated with better oncological outcome compared with salvage radiation therapy in patients with pN1 prostate cancer treated with radical prostatectomy.
BJU Int. 2017; 119(5):717-723
Doi: 10.1111/bju.13679
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Ahyai Sascha
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- Abstract:
- OBJECTIVE: To analyse the comparative effectiveness of no treatment (NT) or salvage radiation therapy (sRT) at biochemical recurrence (BCR) vs adjuvant radiation therapy (aRT) in patients with lymph node (LN)-positive prostate cancer (PCa) after radical prostatectomy (RP). PATIENTS AND METHODS: A total of 773 patients with LN-positive PCa at RP, with or without additional radiation therapy (RT), in the period 2005-2013, were retrospectively analysed. Cox regression analysis was used to assess factors influencing BCR and metastasis-free survival (MFS). Propensity score-matched analyses were performed. RESULTS: The median follow-up for the entire patient group was 33.8 months. Four-year BCR-free and MFS rates were 43.3% and 86.6%, respectively, for all patients. In multivariate analysis, NT/sRT (n = 505) was an independent risk factor for BCR and metastasis compared with aRT (n = 213). The superiority of aRT was confirmed after propensity score matching. The 4-year MFS in the matched cohort was 82.5% vs 91.8% for the NT/sRT and aRT groups, respectively (P = 0.02). Early sRT (pre-RT prostate-specific antigen [PSA] ≤0.5 ng/mL) compared with sRT at PSA >0.5 ng/mL was significantly associated with a lower risk of metastasis. CONCLUSION: Patients with LN-positive PCa who received aRT had a significantly better oncological outcome than patients with NT/sRT, independent of tumour characteristics. Patients with early sRT had higher rates of response and better MFS than patients with pre-RT PSA >0.5 ng/mL.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged - administration & dosage
- Combined Modality Therapy - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Neoplasm Recurrence, Local - blood
- Neoplasm Staging - administration & dosage
- Prostate-Specific Antigen - blood
- Prostatectomy - methods
- Prostatic Neoplasms - blood, pathology, radiotherapy, surgery
- Radiotherapy, Adjuvant - administration & dosage
- Retrospective Studies - administration & dosage
- Salvage Therapy - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- prostate cancer
- lymph node metastasis
- radical prostatectomy
- adjuvant radiation therapy
- salvage radiation therapy
- oncological outcome