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SHR Neuro Cancer Cardio Lipid Metab Microb
Goldacker, S; Draeger, R; Warnatz, K; Huzly, D; Salzer, U; Thiel, J; Eibel, H; Schlesier, M; Peter, HH.
Active vaccination in patients with common variable immunodeficiency (CVID).
CLIN IMMUNOL. 2007; 124(3): 294-303.
Doi: 10.1016/j.clim.2007.04.011
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Thiel Jens
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- Abstract:
- Active vaccination of CVID patients with standard vaccines has rarely been studied in depth although some patients have been shown to develop transient vaccine-specific immunity. We addressed the question whether these patients can be identified by functional classification of their B cell subsets in vitro. Twenty-one CVID patients receiving regular IgG substitution were immunized with anti-peptide and anti-polysaccharide vaccines. Humoral vaccination responses were compared to the numbers of circulating memory B cells, CD21(low) B cells and the capacity to produce antibodies in vitro. Our findings allow four conclusions: (1) positive vaccination responses are not contradictory to the diagnosis of CVID; they occurred against polypeptide vaccines in 23% and against polysaccharide antigens in 18% of all vaccinations. (2) Class-switched antibody responses occur preferentially in patients of CVID group II. (3) A normal percentage of IgM memory B cells is necessary but not sufficient for a vaccination response to polysaccharide antigens. (4) Active vaccination in addition to IgG replacement therapy should be performed in patients of CVID type II - especially in case of vaccines for which passive protection cannot be guaranteed.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Aged - administration & dosage
- Antibody Formation - immunology
- B-Lymphocytes - classification, immunology
- Common Variable Immunodeficiency - classification, immunology, therapy
- Female - administration & dosage
- Humans - administration & dosage
- Immunoglobulin G - blood
- Immunoglobulin M - blood
- Immunologic Memory - administration & dosage
- Lymphocyte Subsets - classification, immunology
- Male - administration & dosage
- Middle Aged - administration & dosage
- Peptides - therapeutic use
- Pneumococcal Vaccines - therapeutic use
- Polysaccharides - therapeutic use
- Streptococcus pneumoniae - immunology
- Vaccination - administration & dosage
- Find related publications in this database (Keywords)
- CVID
- vaccination
- pneumococcal
- polysaccharides
- polypeptides
- IgM memory B cells