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SHR Neuro Cancer Cardio Lipid Metab Microb
Fourtanier, A; Moyal, D; Maccario, J; Compan, D; Wolf, P; Quehenberger, F; Cooper, K; Baron, E; Halliday, G; Poon, T; Seed, P; Walker, SL; Young, AR.
Measurement of sunscreen immune protection factors in humans: a consensus paper.
J INVEST DERMATOL. 2005; 125(3): 403-409.
Doi: 10.1111/j.0022-202X.2005.23857.x
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- Co-authors Med Uni Graz
- Quehenberger Franz
- Wolf Peter
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- Abstract:
- It is increasingly accepted that sunscreens should protect against ultraviolet radiation (UVR)-induced immunosuppression, with an index of protection that can be compared with the sun protection factor (SPF). Five groups of immunoprotection researchers met to discuss the status of immune protection factor (IPF) evaluation in human skin in vivo. Current methods rely on a suncreen's inhibition of UVR-induced local suppression of the contact hypersensitivity (CHS) response or the delayed-type hypersensitivity (DTH) response, using either the induction or the elicitation arms of these responses. The induction arm of the CHS response has the advantage of being sensitive to a single sub-erythemal exposure of solar-simulating radiation (SSR) that allows a direct comparison with the SPF. This approach, which necessitates sensitization, requires a large number of volunteers and is too labor intensive and time consuming to become a routine method. The elicitation arm of the CHS or DTH responses exploits prior sensitization to contact or recall antigens and has the advantage of being possible to apply on small groups of volunteers. Some current protocols, however, require repeat SSR exposures, which invalidates a direct comparison with SPF that is based on a single exposure. There is a need for a new simpler method of IPF that will have to be validated against existing models.
- Find related publications in this database (using NLM MeSH Indexing)
- Dermatitis, Contact - immunology
- Humans - immunology
- Hypersensitivity, Delayed - immunology
- Immune System - drug effects
- Immune Tolerance - drug effects
- Immunologic Factors - analysis
- Immunologic Techniques - analysis
- Skin Neoplasms - immunology
- Sunlight - immunology
- Sunscreening Agents - pharmacology
- Ultraviolet Rays - pharmacology
- Find related publications in this database (Keywords)
- consensus paper
- immune protection
- sunscreens
- ultraviolet radiation