Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aigner, RM; Fueger, GF; Nicoletti, R.
Parathyroid scintigraphy: comparison of technetium-99m methoxyisobutylisonitrile and technetium-99m tetrofosmin studies.
Eur J Nucl Med. 1996; 23(6):693-696
Doi: 10.1007/BF00834533
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Aigner Reingard
- Co-Autor*innen der Med Uni Graz
- Nicoletti Rudolf
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- Abstract:
- We report the preliminary results of a prospective study demonstrating tetrofosmin uptake in surgically and histologically proven parathyroid adenomas. In ten patients with primary chronic hyperparathyroidism, parathyroid imaging was performed using (1) technetium-99m methoxyisobutylisonitrile (MIBI) and (2) 99mTc-1, 2-bis(bis(2-ethoxyethyl)phosphino)ethane (tetrofosmin) within a time interval of 3-5 days. Both tracers correctly identified the parathyroid adenomas by focal prolonged tracer retention. On visual inspection image contrast was generally higher with MIBI than with tetrofosmin in all the patients studied. Tetrofosmin showed a slower elimination from the parathyroid adenomas than MIBI in six of the ten cases. Our preliminary results show that tetrofosmin, like MIBI, as a feasible, sensitive tracer for parathyroid scintigraphy. For routine use, the rapid kit preparation without heating and the lower radiation dose to the patient make tetrofosmin an alternative tracer for parathyroid scintigraphy. Further evaluation is needed to determine which of the two tracers is the more sensitive for the detection of parathyroid adenomas, and which tracer properties better reflect the degree of endocrine activity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenoma - radionuclide imaging
- Aged -
- Female -
- Humans -
- Image Processing, Computer-Assisted -
- Male -
- Middle Aged -
- Organophosphorus Compounds - diagnostic use
- Organotechnetium Compounds - diagnostic use
- Parathyroid Neoplasms - radionuclide imaging
- Prospective Studies -
- Technetium Tc 99m Sestamibi - diagnostic use
- Find related publications in this database (Keywords)
- Tc-99m Methoxyisobutylisonitrile
- Tc-99m 1
- -bis(bis(2-Ethoxyethyl)Phosphino)Ethane
- Parathyroid Adenoma
- Hyperparathyroidism