Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schmidt, H; Schmidt, R; Niederkorn, K; Gradert, A; Schumacher, M; Watzinger, N; Hartung, HP; Kostner, GM.
Paraoxonase PON1 polymorphism leu-Met54 is associated with carotid atherosclerosis: results of the Austrian Stroke Prevention Study.
Stroke. 1998; 29(10):2043-2048
Doi: 10.1161/01.STR.29.10.2043
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Schmidt Helena
- Co-Autor*innen der Med Uni Graz
- Kostner Gerhard
- Niederkorn Kurt
- Schmidt Reinhold
- Schumacher Martin
- Watzinger Norbert
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- BACKGROUND and PURPOSE: Genetic polymorphism at the paraoxonase locus is associated with serum concentration and activity of paraoxonase and with increased risk for coronary heart disease. Two frequent polymorphisms present at the paraoxonase gene are the methionine (M allele) leucine (L allele) interchange at position 54 and the arginine (B allele) glutamine (A allele) interchange at position 191. This is the first study to determine the effect of these polymorphisms on carotid atherosclerosis. METHODS: The paraoxonase genotypes at positions 54 and 191 of 316 randomly selected individuals aged 44 to 75 years were determined by polymerase chain reaction-based restriction enzyme digestion. Carotid atherosclerosis was assessed by color-coded Duplex scanning and was graded on a 5-point scale ranging from 0 (normal) to 5 (complete luminal obstruction). RESULTS: The LL, LM, and MM genotypes at position 54 were noted in 137 (43.4%), 132 (41.8%), and 47 (14.9%) subjects; the AA, AB, and BB genotypes at position 191 occurred in 172 (54.4%), 124 (39.2%), and 20 (6.3%) individuals. The LL genotype was significantly associated with the presence and severity of carotid disease (P=0.022), whereas the 191 polymorphism had no effect. Logistic regression analysis with age and sex forced into the model demonstrated plasma fibrinogen (odds ratio [OR], 1.005 per mg/dL), LDL cholesterol (OR, 1.01 per mg/dL), cardiac disease (OR, 1.75), and the paraoxonase LL genotype to be significant predictors of carotid atherosclerosis. The ORs for the associations with age and sex were 1.09 (P=0.0003) and 1.66 (P=0.052) per year. CONCLUSIONS: These data suggest that the paraoxonase LL genotype may represent a genetic risk factor for carotid atherosclerosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Alleles -
- Amino Acid Sequence -
- Arteriosclerosis - genetics
- Aryldialkylphosphatase - genetics
- Austria - genetics
- Carotid Artery Diseases - genetics
- Cerebrovascular Disorders - prevention and control
- Esterases - genetics
- Female - genetics
- Genotype - genetics
- Humans - genetics
- Male - genetics
- Middle Aged - genetics
- Polymerase Chain Reaction - genetics
- Polymorphism, Genetic - genetics
- Risk Factors - genetics
- Ultrasonography, Doppler, Duplex - genetics
- Find related publications in this database (Keywords)
- Atherosclerosis
- Carotid Arteries
- Genetics
- Paraoxonase