Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Voortman, MM; Damulina, A; Pirpamer, L; Pinter, D; Pichler, A; Enzinger, C; Ropele, S; Bachmaier, G; Archelos, JJ; Marsche, G; Khalil, M.
Decreased Cerebrospinal Fluid Antioxidative Capacity Is Related to Disease Severity and Progression in Early Multiple Sclerosis.
Biomolecules. 2021; 11(9):
Doi: 10.3390/biom11091264
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- Führende Autor*innen der Med Uni Graz
- Khalil Michael
- Marsche Gunther
- Voortman Margarete Maria
- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
- Bachmaier Gerhard
- Damulina Anna
- Enzinger Christian
- Pichler Alexander
- Pinter Daniela Theresia
- Pirpamer Lukas
- Ropele Stefan
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- Abstract:
- Background: Oxidative stress-induced neuronal damage in multiple sclerosis (MS) results from an imbalance between toxic free radicals and counteracting antioxidants, i.e., antioxidative capacity (AOC). The relation of AOC to outcome measures in MS still remains inconclusive. We aimed to compare AOC in cerebrospinal fluid (CSF) and serum between early MS and controls and assess its correlation with clinical/radiological measures. Methods: We determined AOC (ability of CSF and serum of patients to inhibit 2,2'-azobis(2-amidinopropane) dihydrochloride-induced oxidation of dihydrorhodamine) in clinically isolated syndrome (CIS)/early relapsing-remitting MS (RRMS) (n = 55/11) and non-inflammatory neurological controls (n = 67). MS patients underwent clinical follow-up (median, 4.5; IQR, 5.2 years) and brain MRI at 3 T (baseline/follow-up n = 47/34; median time interval, 3.5; IQR, 2.1 years) to determine subclinical disease activity. Results: CSF AOC was differently regulated among CIS, RRMS and controls (p = 0.031) and lower in RRMS vs. CIS (p = 0.020). Lower CSF AOC correlated with physical disability (r = -0.365, p = 0.004) and risk for future relapses (exp(β) = 0.929, p = 0.033). No correlations with MRI metrics were found. Conclusion: Decreased CSF AOC was associated with increased disability and clinical disease activity in MS. While our finding cannot prove causation, they should prompt further investigations into the role of AOC in the evolution of MS.
- Find related publications in this database (Keywords)
- multiple sclerosis
- cerebrospinal fluid
- serum
- antioxidant activity
- magnetic resonance imaging