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Sant, DW; Sinclair, M; Mungall, CJ; Schulz, S; Zerbino, D; Lovering, RC; Logie, C; Eilbeck, K.
Sequence Ontology terminology for gene regulation.
Biochim Biophys Acta Gene Regul Mech. 2021; 1864(10):194745 Doi: 10.1016/j.bbagrm.2021.194745
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Co-authors Med Uni Graz: Schulz Stefan
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Abstract:: The Sequence Ontology (SO) is a structured, controlled vocabulary that provides terms and definitions for genomic annotation. The Gene Regulation Ensemble Effort for the Knowledge Commons (GREEKC) initiative has gathered input from many groups of researchers, including the SO, the Gene Ontology (GO), and gene regulation experts, with the goal of curating information about how gene expression is regulated at the molecular level. Here we discuss recent updates to the SO reflecting current knowledge. We have developed more accurate human-readable terms (also known as classes), including new definitions, and relationships related to the expression of genes. New findings continue to give us insight into the biology of gene regulation, including the order of events, and participants in those events. These updates to the SO support logical reasoning with the current understanding of gene expression regulation at the molecular level.
Find related publications in this database (using NLM MeSH Indexing): Biological Ontologies - administration & dosage; Gene Expression Regulation - administration & dosage; Locus Control Region - administration & dosage; Regulatory Elements, Transcriptional - administration & dosage
Find related publications in this database (Keywords): Gene regulation; Ontology