Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Likar, R; Krainer, B; Sittl, R.
Challenging the equipotency calculation for transdermal buprenorphine: four case studies.
Int J Clin Pract. 2008; 62(1): 152-6.
Doi: 10.1111/j.1742-1241.2007.01531.x
(- Case Report)
Web of Science
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- Leading authors Med Uni Graz
- Likar Rudolf
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- Abstract:
- AIMS: Opioids produce analgesia via different pain pathways. The aim of these case studies was to address the issue of opioid rotation or switching, raising the important issue of conversion ratios between different compounds and routes of administration. RESULTS: We present two cases of neuropathic pain and two cases of nociceptive pain with a significant neuropathic component, which were successfully treated with transdermal buprenorphine after the failure of other opioids. CONCLUSION: In each case, effective pain relief was produced by a lower dose than the proposed equipotency ratio of 1:75 would indicate, suggesting that a ratio of 1:110 to 1:115 may be more appropriate.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous - administration & dosage
- Aged - administration & dosage
- Analgesics, Opioid - administration & dosage
- Buprenorphine - administration & dosage
- Chronic Disease - administration & dosage
- Drug Administration Schedule - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Male - administration & dosage
- Middle Aged - administration & dosage
- Pain - drug therapy