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Draxler, J; Schuch, M; Paul, A; Sycha, T; Valenta, C; Likar, R; Gustorff, B.
[Topical application of morphine and buprenorphine gel has no effect in the sunburn model].
Schmerz. 2008; 22(5): 571-4. Doi: 10.1007/s00482-008-0660-x
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Co-authors Med Uni Graz: Likar Rudolf
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Abstract:: BACKGROUND: The aim of this placebo-controlled double-blinded cross-over study was to investigate the antihyperalgesic effect of topical morphine and buprenorphine in the sunburn pain model. MATERIAL AND METHODS: The study was designed as a double-blind, placebo-controlled cross-over trial, separated into 2 parts each with 16 volunteers. In part A morphine dissolved in Ultrabas-ultrasic ointment at 3 concentrations (0.1, 0.2, 0.4%) and placebo ointment were applied to 4 UVB-induced erythemas on the thighs. In part B buprenorphine at 3 concentrations (0.01, 0.02 and 0.1%) and placebo dissolved in a gel for transcutaneous application, was applied to 4 erythemas on the thighs. Thermal and mechanical hyperalgesia were assessed in the respective erythema by standardized quantitative sensory testing and opioids were compared to the placebo. RESULTS: Neither morphine nor buprenorphine showed any significant reduction of hyperalgesia in comparison to the placebo. CONCLUSION: The topical application of opioids in this form has no effect on inflamed skin.
Find related publications in this database (using NLM MeSH Indexing): Administration, Topical - administration & dosage; Adult - administration & dosage; Analgesics, Opioid - administration & dosage; Buprenorphine - administration & dosage; Cross-Over Studies - administration & dosage; Dose-Response Relationship, Drug - administration & dosage; Double-Blind Method - administration & dosage; Female - administration & dosage; Gels - administration & dosage; Humans - administration & dosage; Male - administration & dosage; Morphine - administration & dosage; Pain - drug therapy; Sunburn - drug therapy
Find related publications in this database (Keywords): peripheral opioid analgesia; hyperalgesia; sunburn pain model; quantitative sensory testing