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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schlimp, CJ; Pipam, W; Wolrab, C; Ohner, C; Kager, HI; Likar, R.
[Clonidine for remifentanil-induced hyperalgesia: a double-blind randomized, placebo-controlled study of clonidine under intra-operative use of remifentanil in elective surgery of the shoulder].
Schmerz. 2011; 25(3): 290-5.
Doi: 10.1007/s00482-011-1058-8
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Likar Rudolf
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- Abstract:
- BACKGROUND: In the postoperative period, α2-adrenergic agonists have an opioid sparing effect. In a previous, experimental study, it was also shown that clonidine attenuates remifentanil-induced hyperalgesia. In this study, we examined under clinical conditions whether early administration of a single dose of clonidine can inhibit remifentanil-induced hyperalgesia in patients undergoing elective surgery of the shoulder and with continuous intraoperative use of remifentanil. PATIENTS AND METHODS: In this study 40 patients received double-blind and randomized either 150 µg clonidine or placebo intravenously before skin incision. Anaesthesia was maintained with propofol and remifentanil (0.23 ± 0.09 µg/kg body weight/min) and morphine (0.1 mg/kg body weight) was administered 20 min before incision closure. Postoperatively, the patients were given a patient-controlled analgesia pump (PCA) with morphine. RESULTS: Overall morphine consumption as well as overall assessment of pain with the visual analogue scale in the first 24 h postoperatively did not differ significantly between the groups. Isolated pain scores at 12 h and 24 h were significantly enhanced in the clonidine group (p<0.05). CONCLUSION: An early single dose of 150 µg of clonidine did not reduce the postoperative morphine consumption and pain scores in patients undergoing elective surgery of the shoulder with remifentanil/propofol-based anaesthesia. After the effect of clonidine has presumably subsided the pain can even increase, therefore further studies with repetitive doses of clonidine should be carried out.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult - administration & dosage
- Analgesia, Patient-Controlled - administration & dosage
- Analgesics - therapeutic use
- Analgesics, Opioid - administration & dosage
- Anesthetics, Intravenous - administration & dosage, adverse effects
- Arthroscopy - administration & dosage
- Austria - administration & dosage
- Clonidine - therapeutic use
- Dose-Response Relationship, Drug - administration & dosage
- Double-Blind Method - administration & dosage
- Female - administration & dosage
- Humans - administration & dosage
- Hyperalgesia - chemically induced, drug therapy
- Male - administration & dosage
- Middle Aged - administration & dosage
- Morphine - administration & dosage
- Pain Measurement - administration & dosage
- Pain, Postoperative - drug therapy
- Piperidines - administration & dosage, adverse effects
- Preanesthetic Medication - administration & dosage
- Remifentanil - administration & dosage
- Shoulder - surgery
- Shoulder Injuries - administration & dosage
- Shoulder Pain - surgery
- Find related publications in this database (Keywords)
- Opioids
- Remifentanil
- Hyperalgesia
- Pain
- postoperative
- Clonidine