Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bsteh, G; Hegen, H; Altmann, P; Auer, M; Berek, K; Di Pauli, F; Wurth, S; Zinganell, A; Rommer, P; Deisenhammer, F; Leutmezer, F; Berger, T.
Retinal layer thinning is reflecting disability progression independent of relapse activity in multiple sclerosis
MULT SCLER J-EXP TRA. 2020; 6(4): 2055217320966344
Doi: 10.1177/2055217320966344
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- Co-Autor*innen der Med Uni Graz
- Wurth Sebastian
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- Abstract:
- Background PIRA (progression independent of relapse) has emerged as a term to quantify the proportion of disability worsening due to non-inflammatory neurodegenerative processes in multiple sclerosis (MS). Objective To determine the impact of PIRA on retinal thinning, a biomarker of neuroaxonal degeneration in MS, in comparison to traditional disability worsening and relapse. Methods In a 4-year, prospective observational study including 171 relapsing MS (RMS) patients, retinal thinning was determined by annual spectral-domain optical coherence tomography measuring macular ganglion-cell-and-inner-plexiform-layer (GCIPL) and peripapillary-retinal-nerve-fibre-layer (pRNFL). PIRA was defined as an expanded disability status scale (EDSS) or symbol digit modalities test (SDMT) worsening confirmed after 24weeks with no relapse in the 30days before or after the disability worsening. Results Each PIRA event was associated with a mean additional loss of GCIPL (1.8 mu m) and pRNFL (1.9 mu m), similar to the impact of EDSS and SDMT worsening. Overall relapse and relapse without subsequent EDSS worsening did not influence retinal thinning, while a relapse with EDSS worsening was associated with an additional loss of GCIPL (1.3 mu m) and pRNFL (1.4 mu m). Conclusions PIRA is associated with retinal thinning, likely reflecting neurodegenerative processes, not directly associated with focal inflammation. It might be a clinical measure to identify MS patients with ongoing MS-associated neurodegeneration.
- Find related publications in this database (Keywords)
- progression independent of relapse activity
- multiple sclerosis
- optical coherence tomography
- retinal thinning
- biomarker
- progression