Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Liebi, M; Lutz-Bueno, V; Guizar-Sicairos, M; Schönbauer, BM; Eichler, J; Martinelli, E; Löffler, JF; Weinberg, A; Lichtenegger, H; Grünewald, TA.
3D nanoscale analysis of bone healing around degrading Mg implants evaluated by X-ray scattering tensor tomography.
Acta Biomater. 2021; 134:804-817
Doi: 10.1016/j.actbio.2021.07.060
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Eichler Johannes
- Martinelli Elisabeth
- Weinberg Annelie-Martina
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- Abstract:
- The nanostructural adaptation of bone is crucial for its biocompatibility with orthopedic implants. The bone nanostructure also determines its mechanical properties and performance. However, the bone's temporal and spatial nanoadaptation around degrading implants remains largely unknown. Here, we present insights into this important bone adaptation by applying scanning electron microscopy, elemental analysis, and small-angle X-ray scattering tensor tomography (SASTT). We extend the novel SASTT reconstruction method and provide a 3D scattering reciprocal space map per voxel of the sample's volume. From this reconstruction, parameters such as the thickness of the bone mineral particles are quantified, which provide additional information on nanostructural adaptation of bone during healing. We selected a rat femoral bone and a degrading ZX10 magnesium implant as model system, and investigated it over the course of 18 months, using a sham as control. We observe that the bone's nanostructural adaptation starts with an initially fast interfacial bone growth close to the implant, which spreads by a re-orientation of the nanostructure in the bone volume around the implant, and is consolidated in the later degradation stages. These observations reveal the complex bulk bone-implant interactions and enable future research on the related biomechanical bone responses. STATEMENT OF SIGNIFICANCE: Traumatic bone injuries are among the most frequent causes of surgical treatment, and often require the placement of an implant. The ideal implant supports and induces bone formation, while being mechanically and chemically adapted to the bone structure, ensuring a gradual load transfer. While magnesium implants fulfill these requirements, the nanostructural changes during bone healing and implant degradation remain not completely elucidated. Here, we unveil these processes in rat femoral bones with ZX10 magnesium implants and show different stages of bone healing in such a model system.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Bone and Bones - administration & dosage
- Magnesium - pharmacology
- Prostheses and Implants - administration & dosage
- Rats - administration & dosage
- Tomography, X-Ray - administration & dosage
- X-Rays - administration & dosage
- Find related publications in this database (Keywords)
- Biomineralization
- Implant degradation
- X-ray scattering
- Tomography
- Degradable magnesium implants