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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Moser, O; Eckstein, ML; Mueller, A; Tripolt, NJ; Yildirim, H; Abbas, F; Pferschy, PN; Goswami, N; Aberer, F; Obermayer, A; Pieber, TR; Kojzar, H; Sourij, C; Brunner, M; Niedrist, T; Herrmann, M; Sourij, H.
Impact of a Single 36 Hours Prolonged Fasting Period in Adults With Type 1 Diabetes - A Cross-Over Controlled Trial.
FRONT ENDOCRINOL. 2021; 12: 656346
Doi: 10.3389/fendo.2021.656346
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- Leading authors Med Uni Graz
- Moser Othmar
- Sourij Harald
- Co-authors Med Uni Graz
- Abbas Farah
- Aberer Felix
- Brunner Martina
- Eckstein Max Lennart
- Goswami Nandu
- Herrmann Markus
- Kojzar Harald
- Müller Alexander
- Niedrist Tobias Josef
- Pferschy Peter
- Pieber Thomas
- Ramirez-Obermayer Anna Maria Antonia
- Sourij Caren
- Tripolt Norbert
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- Abstract:
- Prolonged fasting has shown beneficial effects in healthy individuals and in people with chronic diseases. In type 1 diabetes, the effect or even the feasibility of fasting is unclear. We aimed to assess the impact and safety of prolonged fasting in adults with type 1 diabetes. Glycemia was assessed during overnight fasting (12 hours) vs. prolonged fasting (36 hours) via an intermittently-scanned continuous glucose monitoring system. Anthropometric data, metabolic and hormonal markers were compared between both trial arms. After each fasting period, a 75 g oral glucose tolerance test was performed and plasma glucose levels and hormones were assessed. Data were compared via paired t-tests and mixed-model regressions (p ≤ 0.05). Twenty individuals with type 1 diabetes (7 females) with a mean ± SD age of 35 ± 11 years, body mass index (BMI) 24.8 ± 2.8 kg/m2 and HbA1c 54 ± 7 mmol/mol were included. Hypoglycemia/hour (70 mg/dL; <3.9 mmol/L) was similar in both trial arms (12 hrs: 0.07 ± 0.06 vs. 36 hrs: 0.05 ± 0.03, p=0.21). Glycemic excursions during the oral glucose tolerance test were not different after the two fasting periods. Beta-hydroxybutyrate levels were higher after prolonged fasting (p=0.0006). Our study showed that people with type 1 diabetes can safely perform a 36 hours fasting period with a low risk of hypoglycemia and ketoacidosis. Clinical Trial Registration: DRKS.de, identifier DRKS00016148.
- Find related publications in this database (Keywords)
- fasting
- type 1 diabetes
- CGM
- safety
- OGTT (oral glucose tolerance test)