Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Kitko, CL; Pidala, J; Schoemans, HM; Lawitschka, A; Flowers, ME; Cowen, EW; Tkaczyk, E; Farhadfar, N; Jain, S; Steven, P; Luo, ZHK; Ogawa, Y; Stern, M; Yanik, GA; Cuvelier, GDE; Cheng, GS; Holtan, SG; Schultz, KR; Martin, PJ; Lee, SJ; Pavletic, SZ; Wolff, D; Paczesny, S; Blazar, BR; Sarantopoulos, S; Socie, G; Greinix, H; Cutler, C.
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report
TRANSPL CELL THER. 2021; 27(7): 545-557. Doi: 10.1016/j.jtct.2021.03.033 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Greinix Hildegard
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Abstract:: Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by the National Institutes of Health (NIH) 2005 and 2014 consensus projects has helped improve diagnostic accuracy and severity scoring for clinical trials, but utilization of these tools in routine clinical practice is variable. Additionally, when patients meet the NIH diagnostic criteria, many already have significant morbidity and possibly irreversible organ damage. The goals of this early diagnosis project are 2-fold. First, we provide consensus recommendations regarding implementation of the current NIH diagnostic guidelines into routine transplant care, outside of clinical trials, aiming to enhance early clinical recognition of chronic GVHD. Second, we propose directions for future research efforts to enable discovery of new, early laboratory as well as clinical indicators of chronic GVHD, both globally and for highly morbid organ-specific manifestations. Identification of early features of chronic GVHD that have high positive predictive value for progression to more severe manifestations of the disease could potentially allow for future pre-emptive clinical trials. (C) 2021 The American Society for Transplantation and Cellular Therapy.
Find related publications in this database (Keywords): Chronic graft-versus-host disease; Allogeneic hematopoietic cell transplantation; Consensus; Early diagnosis