Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schmidt, K; Graier, WF; Kostner, GM; Mayer, B; Böhme, E; Kukovetz, WR.
Oxidized low-density lipoprotein antagonizes the activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor but does not interfere with its biosynthesis.
Cell Signal. 1991; 3(4):361-367
Doi: 10.1016/0898-6568(91)90065-3
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- Co-Autor*innen der Med Uni Graz
- Graier Wolfgang
- Kostner Gerhard
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- Abstract:
- Oxidized low-density lipoprotein (LDLox) is a molecule with strong atherogenic properties. In a concentration dependent fashion, LDLox antagonized the activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor (EDRF), which was produced in vitro by incubation of a partially purified EDRF-forming enzyme in the presence of L-arginine, Ca2+ and NADPH. The inhibitory effect of LDLox was potentiated by preincubation of the soluble guanylate cyclase with LDLox, but not when the EDRF-forming enzyme was pretreated with LDLox. As LDLox did not diminish the calmodulin-dependent conversion of L-arginine into L-citrulline by the EDRF-forming enzyme it would appear that EDRF-biosynthesis was not affected by LDLox. It is suggested that the impaired relaxant response of atherosclerotic blood vessels to endothelium-dependent vasodilators was not due to a reduced formation of EDRF but due to a diminished responsiveness of soluble guanylate cyclase.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Enzyme Activation -
- Female -
- Guanylate Cyclase - antagonists and inhibitors
- Humans - antagonists and inhibitors
- Kinetics - antagonists and inhibitors
- Lipoproteins, LDL - physiology
- Male - physiology
- Nitric Oxide - physiology
- Oxidation-Reduction - physiology
- Solubility - physiology
- Swine - physiology
- Find related publications in this database (Keywords)
- EDRF
- Soluble Guanylate Cyclase
- Oxidized LDL
- Atherosclerosis