Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Husic, R; Finzel, S; Stradner, MH; Dreu, M; Hofmeister, A; Beham-Schmid, C; Graninger, WB; Fessler, J; Dejaco, C.
Ultrasound in osteoarthritis of the hand: a comparison to computed tomography and histology.
Rheumatology (Oxford). 2022; 61(SI):SI73-SI80
Doi: 10.1093/rheumatology/keab526
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Husic Rusmir
- Stradner Martin Helmut
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Dejaco Christian
- Dreu Manuel
- Fessler Johannes
- Graninger Winfried
- Hofmeister Alexander
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- OBJECTIVE: To compare structural findings between US, micro-CT (µCT) and histology in people with OA of the hands. METHODS: We analysed DIP and PIP joints of 31 fingers from 15 dissecting-room cadavers with OA of the hands. The occurrence of bone erosions and osteophytes were recorded by US, µCT and histology at 16 regions for each joint and compared for each method. RESULTS: In total, US (n = 558, 56.2% of 992 examined regions) and µCT (n = 493, 49.7%) detected a higher frequency of osteophytes at PIP and DIP joints than histology (n = 161, 23.4% of 689 histological examined regions; P = 0.01). We found a comparable number of erosions with each method [US, n = 52 (5.2%); µCT, n = 43 (4.3%); histology, n = 35 (5.2%)]. Both imaging techniques correlated moderately with each other regarding the detection of osteophytes (r = 0.54, P = 0.002) and erosions (r = 0.43, P = 0.017). Neither US nor µCT correlated with histology regarding erosions or osteophytes. With histology as the reference, US had a sensitivity of 80% and a specificity of 32% to detect osteophytes, whereas µCT had a sensitivity of 73% and a specificity of 27%. For erosions, sensitivities (US 10% and µCT 6%, respectively) were much lower. Microscopically, erosions contained fibrous myxoid tissue extending from subcortical cavities through the breach of cortical bone. CONCLUSIONS: The ability of US to identify osteophytes was comparable to that of µCT, yielding a good sensitivity when histology was used as the gold standard. The sensitivity of US and µCT to detecting erosions was low compared with histology.
- Find related publications in this database (using NLM MeSH Indexing)
- Hand - pathology
- Humans - administration & dosage
- Osteoarthritis - diagnostic imaging, pathology
- Osteophyte - diagnostic imaging, pathology
- Tomography, X-Ray Computed - administration & dosage
- Ultrasonography - methods
- Find related publications in this database (Keywords)
- ultrasonography
- osteoarthritis of the hands
- bone erosions
- micro-computed tomography