Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, MA; Herbsthofer, L; Granegger, B; Goda, M; Brcic, I; Bergovec, M; Scheipl, S; Prietl, B; Pichler, M; Gerger, A; Rossmann, C; Riedl, J; Tomberger, M; López-García, P; El-Heliebi, A; Leithner, A; Liegl-Atzwanger, B; Szkandera, J.
T-regulatory cells predict clinical outcome in soft tissue sarcoma patients: a clinico-pathological study.
Br J Cancer. 2021; 125(5):717-724
Doi: 10.1038/s41416-021-01456-0
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- Führende Autor*innen der Med Uni Graz
- Smolle Maria Anna
- Szkandera Joanna
- Co-Autor*innen der Med Uni Graz
- Bergovec Marko
- Brcic Iva
- El-Heliebi Amin
- Gerger Armin
- Leithner Andreas
- Liegl-Atzwanger Bernadette
- Lopez Garcia Pablo
- Pichler Martin
- Prietl Barbara
- Riedl Jakob
- Roßmann Christopher Herbert
- Scheipl Susanne
- Tomberger Martina
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- Abstract:
- BACKGROUND: Soft tissue sarcomas (STS) are generally considered non-immunogenic, although specific subtypes respond to immunotherapy. Antitumour response within the tumour microenvironment relies on a balance between inhibitory and activating signals for tumour-infiltrating lymphocytes (TILs). This study analysed TILs and immune checkpoint molecules in STS, and assessed their prognostic impact regarding local recurrence (LR), distant metastasis (DM), and overall survival (OS). METHODS: One-hundred and ninety-two surgically treated STS patients (median age: 63.5 years; 103 males [53.6%]) were retrospectively included. Tissue microarrays were constructed, immunohistochemistry for PD-1, PD-L1, FOXP3, CD3, CD4, and CD8 performed, and staining assessed with multispectral imaging. TIL phenotype abundance and immune checkpoint markers were correlated with clinical and outcome parameters (LR, DM, and OS). RESULTS: Significant differences between histology and all immune checkpoint markers except for FOXP3+ and CD3-PD-L1+ cell subpopulations were found. Higher levels of PD-L1, PD-1, and any TIL phenotype were found in myxofibrosarcoma as compared to leiomyosarcoma (all p < 0.05). The presence of regulatory T cells (Tregs) was associated with increased LR risk (p = 0.006), irrespective of margins. Other TILs or immune checkpoint markers had no significant impact on outcome parameters. CONCLUSIONS: TIL and immune checkpoint marker levels are most abundant in myxofibrosarcoma. High Treg levels are independently associated with increased LR risk, irrespective of margins.
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