Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E.
Premature ovarian insufficiency: diagnosis, sequelae, and treatment
AUST J CLIN ENDOCR M. 2021;
Doi: 10.1007/s41969-021-00136-x
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
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- Abstract:
- Premature ovarian insufficiency is a clinical syndrome defined by loss of ovarian function before age 40 with a prevalence of approximately 2%. The diagnosis of premature ovarian insufficiency is based on the presence of estrogen deficiency symptoms, menstrual disturbances (oligo/amenorrhea for at least four months), and biochemical confirmation (elevated FSH level > 25 IU/l on two occasions > 4 weeks apart). The known origins of premature ovarian insufficiency include genetic abnormalities, autoimmune disease as well as medical or surgical causes. However, in a significant number of women the cause is not identified and affected women have idiopathic premature ovarian insufficiency. Women with premature ovarian insufficiency suffer from vasomotor signs, disturbed sleep, reproductive complications, cognitive impairment, and depression. Moreover, untreated POI is associated with an increased risk of osteoporosis, cardiovascular disease, and mortality. Hormone replacement therapy is indicated for the treatment of estrogen-deficiency symptoms as well as for the prevention of osteoporosis and cardiovascular disease in women with POI until the age of natural menopause. The use of transdermal 17 beta-estradiol (in combination with progestogen in women with an intact uterus) is preferred to ethinylestradiol. Women with POI should be advised to adopt lifestyle measures that focus on balanced nutrition, exercise, and avoidance of smoking in order to reduce the possible risk of osteoporosis and cardiovascular disease.
- Find related publications in this database (Keywords)
- Premature menopause
- Early menopause
- Hormone replacement therapy
- Osteoporosis
- Cardiovascular disease