Medizinische Universität Graz - Research portal

Go directly to the nagivation.
Go directly to the content.

Navigation/Search

Selected Publication:

SHR Neuro Cancer Cardio Lipid Metab Microb

Brcic, L; Klikovits, T; Megyesfalvi, Z; Mosleh, B; Sinn, K; Hritcu, R; Laszlo, V; Cufer, T; Rozman, A; Kern, I; Mohorcic, K; Jakopovic, M; Samarzija, M; Seiwerth, S; Kolek, V; Fischer, O; Jakubec, P; Škarda, J; Gieszer, B; Hegedus, B; Fillinger, J; Renyi-Vamos, F; Buder, A; Bilecz, A; Berger, W; Grusch, M; Hoetzenecker, K; Klepetko, W; Hoda, MA; Filipits, M; Dome, B.
Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study.
Transl Lung Cancer Res. 2021; 10(4): 1594-1607. Doi: 10.21037/tlcr-20-1114 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Leading authors Med Uni Graz: Brcic Luka
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: Programmed cell death 1/programmed death ligand 1 (PD-1/PD-L1) immune-checkpoint blockade is a promising new therapeutic strategy in cancer. However, expression patterns and prognostic significance of PD-L1 and PD-1 are still controversial in human malignant pleural mesothelioma (MPM). Formalin-fixed paraffin-embedded (FFPE) tumor samples from 203 MPM patients receiving standard treatment without immunotherapy were collected from 5 European centers. PD-L1 and PD-1 expression of tumor cells (TCs) and tumor-infiltrating lymphocytes (TILs) were measured by immunohistochemistry and correlated with clinical parameters and long-term outcome. High (>10%) PD-L1 TC and PD-1 TILs expressions were found in 18 (8%) and 39 (24%) patients, respectively. PD-L1 was rarely expressed by TILs [≥1%, n=13 (8%); >10%, n=1]. No significant associations were found between the PD-L1 or PD-1 expression of TCs or TILs and clinicopathological parameters such as stage or histological subtype. Notably, patients with high (>10%) TC-specific PD-L1 expression exhibited significantly worse median overall survival (OS) (6.3 vs. 15.1 months of those with low TC PD-L1 expression; HR: 2.51, P<0.001). In multivariate cox regression analysis adjusted for clinical parameters, high TC PD-L1 expression (>10%) proved to be an independent negative prognostic factor for OS (HR: 2.486, P=0.005). There was no significant correlation between PD-L1 or PD-1 expression of TILs and OS. In this multicenter cohort study, we demonstrate that high (>10%) PD-L1 expression of TCs independently predicts worse OS in MPM. Further studies are warranted to investigate the value of PD-L1/PD-1 expression as a marker for treatment response in MPM patients receiving immunotherapy. 2021 Translational Lung Cancer Research. All rights reserved.
Find related publications in this database (Keywords): Malignant pleural mesothelioma (MPM); prognosis; programmed death ligand 1 (PD-L1); programmed cell death 1 (PD-1)