Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Waldherr, L; Seitanidou, M; Jakesova, M; Handl, V; Honeder, S; Nowakowska, M; Tomin, T; Rad, MK; Schmidt, T; Distl, J; Birner-Gruenberger, R; Campe, G; Schafer, U; Berggren, M; Rinner, B; Asslaber, M; Ghaffari-Tabrizi-Wizsy, N; Patz, S; Simon, DT; Schindl, R.
Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump
ADV MATER TECHNOL-US. 2021; 2001302
Doi: 10.1002/admt.202001302
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- Führende Autor*innen der Med Uni Graz
- Patz Silke
- Schindl Rainer
- Waldherr Linda
- Co-Autor*innen der Med Uni Graz
- Asslaber Martin
- Birner-Grünberger Ruth
- Distl Joachim
- Ghaffari Tabrizi-Wizsy Nassim
- Handl Verena
- Honeder Sophie
- Nowakowska-Desplantes Marta
- Rinner Beate
- Schäfer Ute
- Schmidt Tony
- Tomin Tamara
- von Campe Gord
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- Abstract:
- Successful treatment of glioblastoma multiforme (GBM), the most lethal tumor of the brain, is presently hampered by (i) the limits of safe surgical resection and (ii) "shielding" of residual tumor cells from promising chemotherapeutic drugs such as Gemcitabine (Gem) by the blood brain barrier (BBB). Here, the vastly greater GBM cell-killing potency of Gem compared to the gold standard temozolomide is confirmed, moreover, it shows neuronal cells to be at least 104-fold less sensitive to Gem than GBM cells. The study also demonstrates the potential of an electronically-driven organic ion pump ("GemIP") to achieve controlled, targeted Gem delivery to GBM cells. Thus, GemIP-mediated Gem delivery is confirmed to be temporally and electrically controllable with pmol min-1 precision and electric addressing is linked to the efficient killing of GBM cell monolayers. Most strikingly, GemIP-mediated GEM delivery leads to the overt disintegration of targeted GBM tumor spheroids. Electrically-driven chemotherapy, here exemplified, has the potential to radically improve the efficacy of GBM adjuvant chemotherapy by enabling exquisitely-targeted and controllable delivery of drugs irrespective of whether these can cross the BBB.
- Find related publications in this database (Keywords)
- electrophoretic drug delivery
- gemcitabine
- glioblastoma multiforme
- organic electronic ion pumps