Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wang, J; Wang, R; Zhang, F; Yin, Y; Mei, L; Song, F; Tao, M; Yue, W; Zhong, W.
Overcoming multidrug resistance by a combination of chemotherapy and photothermal therapy mediated by carbon nanohorns.
J Mater Chem B. 2016; 4(36): 6043-6051.
Doi: 10.1039/c6tb01469k
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Zhang Fangrong
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- Abstract:
- Multidrug resistance (MDR) is a major obstacle to cancer chemotherapy due to the overexpression of P-glycoprotein (P-gp). Herein, etoposide (ETO) was loaded onto oxidized carbon nanohorns (oxCNHs), which were modified by polyethylene glycol (PEG) and further functionalized with the targeting ligand P-gp monoclonal antibody (PA) in an attempt to overcome MDR. The obtained drug delivery system (ETO@oxCNHs/PEG-PA) showed high drug loading efficiency, enhanced drug release under laser irradiation, improved cellular uptake and increased therapeutic effect both in vitro and in vivo. In addition, NIR laser irradiation had a synergistic effect on overcoming MDR. The MDR-overcoming mechanism could be the efficient cellular uptake, enhanced drug release and reduced drug efflux by P-gp. These results demonstrated that ETO@oxCNHs/PEG-PA could be a promising drug delivery system for cancer MDR reversion.