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Hermelijn, S; Kersten, C; Mullassery, D; Muthialu, N; Cobanoglu, N; Gartner, S; Bagolan, P; Mesas Burgos, C; Sgro, A; Heyman, S; Till, H; Suominen, J; Schurink, M; Desender, L; Losty, P; Ertresvag, K; Tiddens, HAWM; Wijnen, RMH; Schnater, M; CONNECT study consortium COS development group; CONNECT study consortium COS development group.
Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey.
BMJ Open. 2021; 11(4): e044544-e044544. Doi: 10.1136/bmjopen-2020-044544 [OPEN ACCESS]
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Co-authors Med Uni Graz: Till Holger
Study Group Members Med Uni Graz:: Singer Georg
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Abstract:: A worldwide lack of consensus exists on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) even though the incidence is increasing. Either a surgical resection is performed or a wait-and-see policy is employed, depending on the treating physician. Management is largely based on expert opinion and scientific evidence is scarce. Wide variations in outcome measures are seen between studies making comparison difficult thus highlighting the lack of universal consensus in outcome measures as well. We aim to define a core outcome set which will include the most important core outcome parameters for paediatric patients with an asymptomatic CPAM. This study will include a critical appraisal of the current literature followed by a three-stage Delphi process with two stakeholder groups. One surgical group including paediatric as well as thoracic surgeons, and a non-surgeon group including paediatric pulmonologists, intensive care and neonatal specialists. All participants will score outcome parameters according to their level of importance and the most important parameters will be determined by consensus. Electronic informed consent will be obtained from all participants. Ethical approval is not required. After the core outcome set has been defined, we intend to design an international randomised controlled trial: the COllaborative Neonatal NEtwork for the first CPAM Trial, which will be aimed at determining the optimal management of patients with asymptomatic CPAM. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.
Find related publications in this database (Keywords): paediatric intensive &; critical care; neonatology; paediatric thoracic medicine; paediatric surgery; paediatric thoracic surgery