Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Borzan, V; Lerchbaum, E; Missbrenner, C; Heijboer, AC; Goschnik, M; Trummer, C; Theiler-Schwetz, V; Haudum, C; Gumpold, R; Schweighofer, N; Obermayer-Pietsch, B.
Risk of Insulin Resistance and Metabolic Syndrome in Women with Hyperandrogenemia: A Comparison between PCOS Phenotypes and Beyond.
J CLIN MED. 2021; 10(4):
Doi: 10.3390/jcm10040829
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- Führende Autor*innen der Med Uni Graz
- Borzan Valentin
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Goschnik Michaela
- Gumpold Roswitha
- Haudum Christoph
- Lerchbaum Elisabeth
- Missbrenner Cornelia
- Schweighofer Natascha
- Theiler-Schwetz Verena
- Trummer Christian
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- Abstract:
- Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in premenopausal women, with a wide spectrum of possible phenotypes, symptoms and sequelae according to the current clinical definition. However, there are women who do not fulfill at least two out of the three commonly used "Rotterdam criteria" and their risk of developing type 2 diabetes or obesity later in life is not defined. Therefore, we addressed this important gap by conducting a retrospective analysis based on 750 women with and without PCOS. We compared four different PCOS phenotypes according to the Rotterdam criteria with women who exhibit only one Rotterdam criterion and with healthy controls. Hormone and metabolic differences were assessed by analysis of variance (ANOVA) as well as logistic regression analysis. We found that hyperandrogenic women have per se a higher risk of developing insulin resistance compared to phenotypes without hyperandrogenism and healthy controls. In addition, hyperandrogenemia is associated with developing insulin resistance also in women with no other Rotterdam criterion. Our study encourages further diagnostic and therapeutic approaches for PCOS phenotypes in order to account for varying risks of developing metabolic diseases. Finally, women with hyperandrogenism as the only symptom should also be screened for insulin resistance to avoid later metabolic risks.
- Find related publications in this database (Keywords)
- PCOS
- hyperandrogenism
- free testosterone
- insulin resistance
- Rotterdam criteria