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Jenks, JD; Nam, HH; Hoenigl, M.
Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches.
Mycoses. 2021; 64(9):1002-1014
Doi: 10.1111/myc.13274
[OPEN ACCESS]
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
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Hönigl Martin
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- Abstract:
- Invasive aspergillosis (IA) is an increasingly recognised phenomenon in critically ill patients in the intensive care unit, including in patients with severe influenza and severe coronavirus disease 2019 (COVID-19) infection. To date, there are no consensus criteria on how to define IA in the ICU population, although several criteria are used, including the AspICU criteria and new consensus criteria to categorise COVID-19-associated pulmonary aspergillosis (CAPA). In this review, we describe the epidemiology of IA in critically ill patients, most common definitions used to define IA in this population, and most common clinical specimens obtained for establishing a mycological diagnosis of IA in the critically ill. We also review the most common diagnostic tests used to diagnose IA in this population, and lastly discuss the most common clinical presentation and imaging findings of IA in the critically ill and discuss areas of further needed investigation.
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Adult - administration & dosage
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Aged - administration & dosage
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Aged, 80 and over - administration & dosage
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Aspergillus - genetics, isolation & purification
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COVID-19 - complications, microbiology
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Critical Illness - classification
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Diagnostic Techniques and Procedures - standards
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Female - administration & dosage
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Humans - administration & dosage
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Intensive Care Units - standards
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Invasive Pulmonary Aspergillosis - classification, diagnosis, physiopathology
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Male - administration & dosage
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Mannans - blood
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Middle Aged - administration & dosage
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Polymerase Chain Reaction - administration & dosage
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Practice Guidelines as Topic - administration & dosage
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SARS-CoV-2 - administration & dosage
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Aspergillus galactomannan lateral flow assay
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Aspergillus‐
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specific lateral flow device
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AspICU criteria
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COVID‐
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associated invasive pulmonary aspergillosis
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critically ill patients
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EORTC
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Galactomannan
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influenza‐
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associated invasive aspergillosis
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intensive care unit
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Invasive aspergillosis
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MSG criteria
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polymerase chain reaction