Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pajed, L; Taschler, U; Tilp, A; Hofer, P; Kotzbeck, P; Kolleritsch, S; Radner, FPW; Pototschnig, I; Wagner, C; Schratter, M; Eder, S; Huetter, S; Schreiber, R; Haemmerle, G; Eichmann, TO; Schweiger, M; Hoefler, G; Kershaw, EE; Lass, A; Schoiswohl, G.
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
Commun Biol. 2021; 4(1):323
Doi: 10.1038/s42003-021-01858-z
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- Führende Autor*innen der Med Uni Graz
- Schoiswohl Gabriele Maria
- Taschler Ulrike
- Co-Autor*innen der Med Uni Graz
- Eichmann Thomas
- Hofer Peter
- Höfler Gerald
- Kotzbeck Petra
- Schreiber Renate
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- Abstract:
- Modulation of adipocyte lipolysis represents an attractive approach to treat metabolic diseases. Lipolysis mainly depends on two enzymes: adipose triglyceride lipase and hormone-sensitive lipase (HSL). Here, we investigated the short- and long-term impact of adipocyte HSL on energy homeostasis using adipocyte-specific HSL knockout (AHKO) mice. AHKO mice fed high-fat-diet (HFD) progressively developed lipodystrophy accompanied by excessive hepatic lipid accumulation. The increased hepatic triglyceride deposition was due to induced de novo lipogenesis driven by increased fatty acid release from adipose tissue during refeeding related to defective insulin signaling in adipose tissue. Remarkably, the fatty liver of HFD-fed AHKO mice reversed with advanced age. The reversal of fatty liver coincided with a pronounced lipodystrophic phenotype leading to blunted lipolytic activity in adipose tissue. Overall, we demonstrate that impaired adipocyte HSL-mediated lipolysis affects systemic energy homeostasis in AHKO mice, whereby with older age, these mice reverse their fatty liver despite advanced lipodystrophy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipocytes - enzymology, pathology
- Age Factors - administration & dosage
- Animals - administration & dosage
- Blood Glucose - metabolism
- Disease Models, Animal - administration & dosage
- Energy Metabolism - administration & dosage
- Fatty Liver - enzymology, genetics, pathology
- Insulin - metabolism
- Lipodystrophy - enzymology, genetics, pathology
- Lipolysis - administration & dosage
- Liver - metabolism, pathology
- Male - administration & dosage
- Mice, Inbred C57BL - administration & dosage
- Mice, Knockout - administration & dosage
- PPAR gamma - metabolism
- Sterol Esterase - deficiency, genetics
- Time Factors - administration & dosage