Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sistilli, G; Kalendova, V; Cajka, T; Irodenko, I; Bardova, K; Oseeva, M; Zacek, P; Kroupova, P; Horakova, O; Lackner, K; Gastaldelli, A; Kuda, O; Kopecky, J; Rossmeisl, M.
Krill Oil Supplementation Reduces Exacerbated Hepatic Steatosis Induced by Thermoneutral Housing in Mice with Diet-Induced Obesity.
NUTRIENTS. 2021; 13(2):
Doi: 10.3390/nu13020437
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- Co-Autor*innen der Med Uni Graz
- Lackner Karoline
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- Abstract:
- Preclinical evidence suggests that n-3 fatty acids EPA and DHA (Omega-3) supplemented as phospholipids (PLs) may be more effective than triacylglycerols (TAGs) in reducing hepatic steatosis. To further test the ability of Omega-3 PLs to alleviate liver steatosis, we used a model of exacerbated non-alcoholic fatty liver disease based on high-fat feeding at thermoneutral temperature. Male C57BL/6N mice were fed for 24 weeks a lard-based diet given either alone (LHF) or supplemented with Omega-3 (30 mg/g diet) as PLs (krill oil; ω3PL) or TAGs (Epax 3000TG concentrate; ω3TG), which had a similar total content of EPA and DHA and their ratio. Substantial levels of TAG accumulation (~250 mg/g) but relatively low inflammation/fibrosis levels were achieved in the livers of control LHF mice. Liver steatosis was reduced by >40% in the ω3PL but not ω3TG group, and plasma ALT levels were markedly reduced (by 68%) in ω3PL mice as well. Krill oil administration also improved hepatic insulin sensitivity, and its effects were associated with high plasma adiponectin levels (150% of LHF mice) along with superior bioavailability of EPA, increased content of alkaloids stachydrine and trigonelline, suppression of lipogenic gene expression, and decreased diacylglycerol levels in the liver. This study reveals that in addition to Omega-3 PLs, other constituents of krill oil, such as alkaloids, may contribute to its strong antisteatotic effects in the liver.
- Find related publications in this database (using NLM MeSH Indexing)
- Animal Nutritional Physiological Phenomena -
- Animals -
- Diet, High-Fat - adverse effects
- Dietary Supplements -
- Disease Models, Animal -
- Euphausiacea -
- Fish Oils - pharmacology
- Housing, Animal -
- Insulin Resistance -
- Liver - metabolism
- Male -
- Mice -
- Mice, Inbred C57BL -
- Non-alcoholic Fatty Liver Disease - etiology
- Non-alcoholic Fatty Liver Disease - therapy
- Obesity - etiology
- Obesity - therapy
- Phospholipids - pharmacology
- Find related publications in this database (Keywords)
- NAFLD
- obesity
- omega-3
- krill oil
- phospholipids
- high-fat diet
- C57BL/6N mice
- thermoneutral temperature