Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ledermann, K; Jenewein, J; Sprott, H; Hasler, G; Schnyder, U; Warnock, G; Johayem, A; Kollias, S; Buck, A; Martin-Soelch, C.
Relation of dopamine receptor 2 binding to pain perception in female fibromyalgia patients with and without depression--A [¹¹C] raclopride PET-study.
Eur Neuropsychopharmacol. 2016; 26(2):320-330
Doi: 10.1016/j.euroneuro.2015.12.007
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Jenewein Josef
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Dopamine D2/D3 receptor availability at rest and its association with individual pain perception was investigated using the [(11)C] raclopride PET-method in 24 female Fibromyalgia (FMS) participants with (FMS+, N=11) and without (FMS-, N=13) comorbid depression and in 17 healthy women. Thermal pain thresholds (TPT) and pain responses were assessed outside the scanner. We compared the discriminative capacity, i.e. the individual׳s capacity to discriminate between lower and higher pain intensities and the response criterion, i.e. the subject׳s tendency to report pain during noxious stimulation due to psychological factors. [(11)C] raclopride binding potential (BP), defined as the ratio of specifically bound non-displaceable radioligand at equilibrium (BP(ND)) was used as measure of D2/D3 receptor availability. We found significant group effects of BP(ND) in striatal regions (left ventral striatum, left caudate nucleus and left nucleus accumbens) between FMS+ and FMS- compared to healthy subjects. Correlational analysis showed negative associations between TPT and D2/D3 receptor availability in the left caudate nucleus in FMS-, between TPT and D2/D3 receptor availability in the right caudate nucleus in FMS + and positive associations between TPT and D2/D3 receptor availability in the left putamen and right caudate nucleus in healthy controls. The response criterion was positively associated with D2/D3 receptor availability in the right nucleus accumbens in FMS - and negatively with D2/D3 receptor availability in the left caudate nucleus in healthy controls. Finally, no significant associations between D2/D3 receptor availability and discriminative capacity in any of the groups or regions were determined. These findings provide further support for a disruption of dopaminergic neurotransmission in FMS and implicate DA as important neurochemical moderator of differences in pain perception in FMS patients with and without co-morbid depression. Copyright © 2015 Elsevier B.V. and ECNP. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Brain - diagnostic imaging
- Brain - pathology
- Depression - complications
- Depression - diagnostic imaging
- Dopamine Antagonists - pharmacokinetics
- Female -
- Fibromyalgia - complications
- Fibromyalgia - diagnostic imaging
- Humans -
- Hyperalgesia - diagnostic imaging
- Magnetic Resonance Imaging -
- Middle Aged -
- Pain Perception - physiology
- Positron-Emission Tomography -
- Raclopride - pharmacokinetics
- Receptors, Dopamine D2 - metabolism
- Find related publications in this database (Keywords)
- D2 receptors
- Pain perception
- Fibromyalgia
- Depression
- PET