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Boettger, S; Nuñez, DG; Meyer, R; Richter, A; Fernandez, SF; Rudiger, A; Schubert, M; Jenewein, J.
Delirium in the intensive care setting and the Richmond Agitation and Sedation Scale (RASS): Drowsiness increases the risk and is subthreshold for delirium.
J Psychosom Res. 2017; 103(8):133-139 Doi: 10.1016/j.jpsychores.2017.09.011
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Co-authors Med Uni Graz: Jenewein Josef
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Abstract:: Sedation is a core concept in the intensive care setting, however, the impact of sedation on delirium has not yet been studied to date. In this prospective cohort study, 225 patients with Richmond Agitation and Sedation (RASS) scores of -1 - drowsiness and 0 - alert- and calmness were assessed with the Delirium Rating Scale-Revised 1998 (DRS-R-98) and DSM-IV-TR-determined diagnosis of delirium assessing drowsiness versus alertness. By itself, drowsiness increased the odds for developing delirium eightfold (OR 7.88 p<0.001) and rates of delirium were 68.2 and 21.4%, respectively. Further, in the drowsy patient, delirium was more severe. In the presence of drowsiness, delirium was characterized by sleep-wake cycle disturbances and language abnormalities. These two features, in addition to psychomotor retardation, allowed the correct classification of delirium at RASS-1. The same features, in addition to thought abnormalities and the impairment in the cognitive domain, orientation, attention, short- and long-term memory representing the core domains of delirium, or the temporal onset were very sensitive towards delirium, however lacked specificity. Conversely, delusions, perceptual abnormalities and lability of affect representing the non-core domain were very specific for delirium in the drowsy, however, not very sensitive. In the absence of delirium, drowsiness caused attentional impairment and language abnormalities. Drowsiness increased the odds for developing delirium eightfold and caused more severe delirium, which was characterized by sleep-wake cycle and language abnormalities. Further, drowsiness by itself caused attentional impairment and language abnormalities, thus, with its disturbance in consciousness was subthreshold for delirium. Copyright © 2017 Elsevier Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Cohort Studies -; Critical Care - psychology; Delirium - diagnosis; Female -; Humans -; Intensive Care Units - statistics & numerical data; Male -; Middle Aged -; Prospective Studies -; Psychomotor Agitation - psychology; Sleep Stages - physiology
Find related publications in this database (Keywords): Delirium; Symptom profile; Intensive Care Unit (ICU); Richmond Agitation and Sedation Scale (BASS); Drowsiness; Alertness; Delirium Rating Scale-Revised 1998 (DRS-R-98)