Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Milovanovic, P; Zimmermann, EA; Vom Scheidt, A; Hoffmann, B; Sarau, G; Yorgan, T; Schweizer, M; Amling, M; Christiansen, S; Busse, B.
The Formation of Calcified Nanospherites during Micropetrosis Represents a Unique Mineralization Mechanism in Aged Human Bone.
Small. 2017; 13(3): 1602215 Doi: 10.1002/smll.201602215
Web of Science PubMed FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: vom Scheidt Annika
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Abstract:: Osteocytes-the central regulators of bone remodeling-are enclosed in a network of microcavities (lacunae) and nanocanals (canaliculi) pervading the mineralized bone. In a hitherto obscure process related to aging and disease, local plugs in the lacuno-canalicular network disrupt cellular communication and impede bone homeostasis. By utilizing a suite of high-resolution imaging and physics-based techniques, it is shown here that the local plugs develop by accumulation and fusion of calcified nanospherites in lacunae and canaliculi (micropetrosis). Two distinctive nanospherites phenotypes are found to originate from different osteocytic elements. A substantial deviation in the spherites' composition in comparison to mineralized bone further suggests a mineralization process unlike regular bone mineralization. Clearly, mineralization of osteocyte lacunae qualifies as a strong marker for degrading bone material quality in skeletal aging. The understanding of micropetrosis may guide future therapeutics toward preserving osteocyte viability to maintain mechanical competence and fracture resistance of bone in elderly individuals. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Find related publications in this database (using NLM MeSH Indexing): Aged, 80 and over -; Aging - pathology; Bone Matrix - ultrastructure; Bone and Bones - pathology; Calcification, Physiologic -; Female -; Humans -; Nanospheres - chemistry; Nanospheres - ultrastructure; Osteocytes - ultrastructure; Osteopetrosis - pathology