Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schmid-Bindert, G; Henzler, T; Chu, TQ; Meyer, M; Nance, JW; Schoepf, UJ; Dinter, DJ; Apfaltrer, P; Krissak, R; Manegold, C; Schoenberg, SO; Fink, C.
Functional imaging of lung cancer using dual energy CT: how does iodine related attenuation correlate with standardized uptake value of 18FDG-PET-CT?
Eur Radiol. 2012; 22(1):93-103
Doi: 10.1007/s00330-011-2230-3
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Apfaltrer Paul
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- Abstract:
- To investigate the correlation between maximum standardized uptake value (SUV(max)) of (18)FDG PET-CT and iodine-related attenuation (IRA) of dual energy CT (DECT) of primary tumours and (18)FDG PET-CT positive thoracic lymph nodes (LN) in patients with lung cancer. 37 patients with lung cancer (27 NSCLC, 10 SCLC, 86 (18)FDG PET-CT positive thoracic LN) who underwent both (18)FDG PET-CT and DECT were analyzed. The mean study interval between (18)FDG PET-CT and DECT was ≤21 days in 17 patients. The mean and maximum IRA of DECT as well as of virtual unenhanced and virtual 120 kV images of DECT was analyzed and correlated to the SUV(max) of (18)FDG PET-CT in all tumours and (18)FDG PET-CT positive thoracic lymph nodes. Further subgroup analysis was performed for histological subtypes in all groups. A moderate correlation was found between SUV(max) and maximum IRA in all tumours (n = 37;r = 0.507;p = 0.025) whereas only weak or no correlation were found between SUV(max) and all other DECT measurements. A strong correlation was found in patients with study intervals ≤21 days (n = 17; r = 0.768;p = 0.017). Analysis of histological subtypes of lung cancer showed a strong correlation between SUV(max) and maximum IRA in the analysis of all patients with NSCLC (r = 0.785;p = 0.001) and in patients with NSCLC and study intervals ≤21 days (r = 0.876;p = 0.024). Thoracic LN showed moderate correlation between SUV(max) and maximum IRA in patients with study intervals ≤21 days (r = 0.654; p = 0.010) whereas a weak correlation was found between SUV(max) and maximum IRA in patients with study intervals >21 days (r = 0.299; p = 0.035). DECT could serve as a valuable functional imaging test for patients with NSCLC as the IRA of DECT correlates with SUV(max) of (18)FDG PET-CT.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Non-Small-Cell Lung - diagnostic imaging
- Carcinoma, Non-Small-Cell Lung - metabolism
- Female -
- Fluorodeoxyglucose F18 - metabolism
- Humans -
- Iodine - metabolism
- Lung Neoplasms - diagnostic imaging
- Lung Neoplasms - metabolism
- Lymphatic Metastasis -
- Male -
- Middle Aged -
- Multimodal Imaging - methods
- Positron-Emission Tomography -
- Prospective Studies -
- Radiopharmaceuticals - metabolism
- Small Cell Lung Carcinoma - diagnostic imaging
- Small Cell Lung Carcinoma - metabolism
- Tomography, X-Ray Computed -
- Find related publications in this database (Keywords)
- Lung cancer
- Dual energy computed tomography
- 18FDG PET-CT
- Tumor vascularity
- Tumour staging