Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Apfaltrer, P; Walter, T; Gruettner, J; Weilbacher, F; Meyer, M; Henzler, T; Neumaier, M; Schoenberg, SO; Fink, C.
Prediction of adverse clinical outcome in patients with acute pulmonary embolism: evaluation of high-sensitivity troponin I and quantitative CT parameters.
Eur J Radiol. 2013; 82(3): 563-567.
Doi: 10.1016/j.ejrad.2012.11.009
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Apfaltrer Paul
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- Abstract:
- To evaluate the accuracy of high-sensitivity-cardiac-troponin-I (hs-cTnI) and quantitative CT-parameters, alone and in combination, for predicting right-ventricular-dysfunction (RVD) and adverse clinical outcome in patients with acute pulmonary embolism (PE). 65 patients with PE and hs-cTnI measurements within 24 h of CT were retrospectively included. RVD was assessed on CT by calculating right ventricular/left ventricular (RV/LV) diameter ratios on transverse sections (RV/LVtrans), four-chamber-views (RV/LV4ch), and RV/LV volume ratio (RV/LVvol). Pulmonary CTA-obstruction-scores (OS) (Qanadli, Mastora) were calculated. Receiver operator characteristic (ROC) analysis was performed to compare Hs-cTnI, RV/LV ratios, and OS for predicting adverse clinical outcome (i.e. intensive care treatment, death). 12 patients with PE had adverse clinical outcome and showed significantly higher RV/LV ratios and OS compared to those without. ROC analysis revealed a cutoff value of 0.042 ng/mL for hs-cTnI resulting in a sensitivity and specificity of 84% and 92% for predicting adverse clinical outcome, respectively. Elevated hs-cTnI was significantly associated with adverse clinical outcome. In a ROC analysis the AUC for the prediction of adverse clinical outcome of RV/LV4Ch, RV/LVvol, and hs-cTnI were 0.77, 0.76, and 0.71. The combination of hs-cTnI and RV/LV ratios increased the AUC for the prediction of adverse clinical outcome. Hs-cTnI is associated with adverse clinical outcome in patients with acute PE. A combination of hs-cTnI with quantitative CT-parameters improves the prediction of adverse clinical outcome. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers - blood
- Female -
- Humans -
- Male -
- Middle Aged -
- Prognosis -
- Pulmonary Embolism - blood
- Pulmonary Embolism - complications
- Pulmonary Embolism - diagnosis
- Reproducibility of Results -
- Retrospective Studies -
- Risk Assessment -
- Sensitivity and Specificity -
- Tomography, X-Ray Computed - methods
- Troponin I - blood
- Ventricular Dysfunction, Right - blood
- Ventricular Dysfunction, Right - diagnosis
- Ventricular Dysfunction, Right - etiology
- Young Adult -
- Find related publications in this database (Keywords)
- Pulmonary embolism
- Right ventricular dysfunction
- Computed tomography
- Adverse clinical outcome
- High-sensitivity cardiac troponin I