Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Meyer, M; Fink, C; Roeger, S; Apfaltrer, P; Haghi, D; Kaminski, WE; Neumaier, M; Schoenberg, SO; Henzler, T.
Benefit of combining quantitative cardiac CT parameters with troponin I for predicting right ventricular dysfunction and adverse clinical events in patients with acute pulmonary embolism.
Eur J Radiol. 2012; 81(11):3294-3299
Doi: 10.1016/j.ejrad.2012.06.023
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Apfaltrer Paul
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- Abstract:
- To prospectively evaluate the diagnostic accuracy of quantitative cardiac CT parameters alone and in combination with troponin I for the assessment of right ventricular dysfunction (RVD) and adverse clinical events in patients with acute pulmonary embolism (PE). This prospective study had institutional review board approval and was HIPAA compliant. In total 83 patients with confirmed PE underwent echocardiography and troponin I serum level measurements within 24 h. Three established cardiac CT measurements for the assessment of RVD were obtained (RV/LVaxial, RV/LV4-CH, and RV/LVvolume). CT measurements and troponin I serum levels were correlated with RVD found on echocardiography and adverse clinical events according to Management Strategies and Prognosis in Pulmonary Embolism Trial-3 (MAPPET-3 criteria. 31 of 83 patients with PE had RVD on echocardiography and 39 of 83 patients had adverse clinical events. A RV/LVvolume ratio>1.43 showed the highest area under the curve (AUC) (0.65) for the prediction of adverse clinical events when compared to RV/LVaxial, RV/LV4Ch and troponin I. The AUC for the detection of RVD of RV/LVaxial, RV/LV4Ch, RV/LVvolume, and troponin I were 0.86, 0.86, 0.92, and 0.69, respectively. Combination of RV/LVaxial, RV/LV4Ch, RV/LVvolume with troponin I increased the AUC to 0.87, 0.87 and 0.93, respectively. A combination of cardiac CT parameters and troponin I measurements improves the diagnostic accuracy for detecting RVD and predicting adverse clinical events if compared to either test alone. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biomarkers - blood
- Coronary Angiography - methods
- Female -
- Humans -
- Male -
- Middle Aged -
- Prognosis -
- Pulmonary Embolism - blood
- Pulmonary Embolism - diagnosis
- Reproducibility of Results -
- Sensitivity and Specificity -
- Tomography, X-Ray Computed - methods
- Troponin I - blood
- Ventricular Dysfunction, Right - blood
- Ventricular Dysfunction, Right - diagnosis
- Young Adult -
- Find related publications in this database (Keywords)
- Pulmonary embolism
- Right ventricular dysfunction
- Computed tomography
- Adverse outcome
- Troponin I