Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Takx, RAP; Vliegenthart, R; Schoepf, UJ; Pilz, LR; Schoenberg, SO; Morris, PB; Henzler, T; Apfaltrer, P.
Coronary artery calcium in breast cancer survivors after radiation therapy.
Int J Cardiovasc Imaging. 2017; 33(9): 1425-1431.
Doi: 10.1007/s10554-017-1119-x
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Apfaltrer Paul
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- Abstract:
- The purpose of the current study is to investigate whether breast cancer survivors after radiation therapy have a higher burden of coronary artery calcium as a potential surrogate of radiation-induced accelerated coronary artery disease. 333 patients were included. 54 patients underwent chest CT ≥ 6 months after the start of radiation therapy (radiation therapy group), while 279 patients had a CT scan either prior to or without undergoing radiation therapy (RT). Coronary artery calcium was quantified from CT by applying a threshold-based automated algorithm. Mean age at diagnosis was similar (p = 0.771) between RT (57.4 ± 13.1 years) and NoRT (58.0 ± 11.9 years). Median time between radiation therapy and CT was 2 years. The groups showed no significant differences in race, smoking history, cancer laterality, or cancer stage. 39 (72.2%) of RT patients had a coronary artery calcium score of 0, compared to 201 (72.0%) in patients without radiation therapy. Median coronary artery calcium burden for both groups was not significantly different (p = 0.982), nor when comparing patients who underwent left- versus right-sided radiation therapy (p = 0.453). When adjusting for the time between diagnosis and CT, radiation therapy patients had a significantly lower risk of a positive coronary artery calcium score. In conclusion, breast cancer survivors after radiation therapy are not more likely to show coronary artery calcium on follow-up CT imaging. Our results thus do not support radiation-induced accelerated coronary artery disease as an explanation for higher rates of heart disease in this group.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Algorithms -
- Breast Neoplasms - radiotherapy
- Cancer Survivors -
- Computed Tomography Angiography -
- Coronary Angiography - methods
- Coronary Artery Disease - diagnostic imaging
- Coronary Artery Disease - etiology
- Coronary Vessels - diagnostic imaging
- Coronary Vessels - radiation effects
- Female -
- Humans -
- Middle Aged -
- Predictive Value of Tests -
- Radiographic Image Interpretation, Computer-Assisted -
- Radiotherapy - adverse effects
- Retrospective Studies -
- Risk Assessment -
- Risk Factors -
- Severity of Illness Index -
- Time Factors -
- Vascular Calcification - diagnostic imaging
- Vascular Calcification - etiology
- Find related publications in this database (Keywords)
- Radiation oncology
- Coronary artery disease
- Breast neoplasms
- Myocardial ischemia
- Radiation therapy