Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zimmermann, A; Tadic, J; Kainz, K; Hofer, SJ; Bauer, MA; Carmona-Gutierrez, D; Madeo, F.
Transcriptional and epigenetic control of regulated cell death in yeast.
Int Rev Cell Mol Biol. 2020; 352(8):55-82
Doi: 10.1016/bs.ircmb.2019.12.003
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zimmermann Andreas
- Co-Autor*innen der Med Uni Graz
- Kainz Katharina
- Tadic Jelena
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- Abstract:
- Unicellular organisms like yeast can undergo controlled demise in a manner that is partly reminiscent of mammalian cell death. This is true at the levels of both mechanistic and functional conservation. Yeast offers the combination of unparalleled genetic amenability and a comparatively simple biology to understand both the regulation and evolution of cell death. In this minireview, we address the capacity of the nucleus as a regulatory hub during yeast regulated cell death (RCD), which is becoming an increasingly central question in yeast RCD research. In particular, we explore and critically discuss the available data on stressors and signals that specifically impinge on the nucleus. Moreover, we also analyze the current knowledge on nuclear factors as well as on transcriptional control and epigenetic events that orchestrate yeast RCD. Altogether we conclude that the functional significance of the nucleus for yeast RCD in undisputable, but that further exploration beyond correlative work is necessary to disentangle the role of nuclear events in the regulatory network. © 2020 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Epigenesis, Genetic - genetics
- Regulated Cell Death - genetics
- Saccharomyces cerevisiae - cytology
- Saccharomyces cerevisiae - genetics
- Saccharomyces cerevisiae - metabolism
- Transcription, Genetic - genetics