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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Cabal, A; Schmid, D; Hell, M; Chakeri, A; Mustafa-Korninger, E; Wojna, A; Stöger, A; Möst, J; Leitner, E; Hyden, P; Rattei, T; Habington, A; Wiedermann, U; Allerberger, F; Ruppitsch, W.
Isolate-Based Surveillance of Bordetella pertussis, Austria, 2018-2020.
Emerg Infect Dis. 2021; 27(3):862-871
Doi: 10.3201/eid2703.202314
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- Co-authors Med Uni Graz
- Leitner-Meyer Eva
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- Abstract:
- Pertussis is a vaccine-preventable disease, and its recent resurgence might be attributable to the emergence of strains that differ genetically from the vaccine strain. We describe a novel pertussis isolate-based surveillance system and a core genome multilocus sequence typing scheme to assess Bordetella pertussis genetic variability and investigate the increased incidence of pertussis in Austria. During 2018-2020, we obtained 123 B. pertussis isolates and typed them with the new scheme (2,983 targets and preliminary cluster threshold of <6 alleles). B. pertussis isolates in Austria differed genetically from the vaccine strain, both in their core genomes and in their vaccine antigen genes; 31.7% of the isolates were pertactin-deficient. We detected 8 clusters, 1 of them with pertactin-deficient isolates and possibly part of a local outbreak. National expansion of the isolate-based surveillance system is needed to implement pertussis-control strategies.