Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Birngruber, T; Sinner, F.
Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue.
Drug Discov Today Technol. 2016; 20(5): 19-25.
Doi: 10.1016/j.ddtec.2016.07.003
PubMed
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- Führende Autor*innen der Med Uni Graz
- Birngruber Thomas
- Co-Autor*innen der Med Uni Graz
- Sinner Frank Michael
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- Abstract:
- Cerebral open flow microperfusion (cOFM) is a new in-vivo technique for continuous sampling of the interstitial fluid in brain tissue. cOFM can be used to monitor substance transport across the blood-brain barrier (pharmacokinetics) and to investigate metabolic changes in brain tissue after drug application (pharmacodynamics). The possibility of long-term implantation into the brain makes cOFM an outstanding tool in the development of brain relevant pharmaceutics. Copyright © 2016 Elsevier Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Brain - metabolism
- Microtechnology - instrumentation
- Microtechnology - methods
- Perfusion - instrumentation
- Perfusion - methods
- Pharmacokinetics -
- Pharmacological and Toxicological Phenomena -