Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rumpler, M; Suppan, M; Hajnsek, M; Satzinger, V; Köstler, S; Sinner, F.
Design and evaluation of a microfluidic-based whole blood pre-treatment module to detect folic acid.
Biomed Tech (Berl). 2013; 58 Suppl 1(12):
Doi: 10.1515/bmt-2013-4137
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Sinner Frank Michael
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- Abstract:
- Haemoglobin interferes with the optical detection of various analytes in human blood. The aim of this study was the design and evaluation of a pre-treatment module which combines the instillation of undiluted whole human blood into a microchannel structure and the subsequent separation of erythrocytes. The microchannel structure on a cyclic olefin polymer (COP) based chip was manufactured by hot embossing or micro-milling. We were able to show that the used material does not adsorb haemoglobin or erythrocytes and that the generated plasma had 67.1% less haemoglobin than the whole blood sample.
- Find related publications in this database (Keywords)
- lab-on-a-chip
- microfluidic
- blood plasma separation
- diagnostics
- haemoglobin adsorption