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Gasser, R; Reisinger, E; Sedaj, B; Horvarth, R; Seinost, G; Keplinger, A; Wendelin, I; Klein, W.
Oral treatment of late Lyme borreliosis with a combination of roxithromycin and co-trimoxazole--a pilot study on 18 patients.
Acta Med Austriaca. 1996; 23(3):99-101
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Leading authors Med Uni Graz: Gasser Robert
Co-authors Med Uni Graz: Seinost Gerald; Wendelin Ilse
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Abstract:: In this pilot trial, 18 patients participated in an investigation in which the combined therapy of co-trimoxazole and roxithromycin in late Lyme borreliosis was tested. The study has been performed as a result of earlier case reports in "The Lancet" where this combination has been used successfully in order to thwart late Lyme disease. The authors show that 76% of the patients recovered completely. In 2 patients, symptoms could be resolved with i.v. penicillin and 2 did not respond to any antibiotic therapy. These results show that oral therapy of co-trimoxazole and roxithromycin in combination provides similar results as i.v. antibiotics in earlier studies.
Find related publications in this database (using NLM MeSH Indexing): Administration, Oral -; Dose-Response Relationship, Drug -; Drug Administration Schedule -; Drug Therapy, Combination - adverse effects; Humans - adverse effects; Lyme Disease - diagnosis; Pilot Projects - diagnosis; Roxithromycin - adverse effects; Trimethoprim-Sulfamethoxazole Combination - adverse effects
Find related publications in this database (Keywords): Roxithromycin; Borrelia Burgdorferi; Lyme Borreliosis; Cotrimoxazole