Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Andrianakis, A; Moser, U; Kiss, P; Holzmeister, C; Andrianakis, D; Tomazic, PV; Wolf, A; Graupp, M.
Comparison of two different intratympanic corticosteroid injection protocols as salvage treatments for idiopathic sudden sensorineural hearing loss.
Eur Arch Otorhinolaryngol. 2022; 279(2):609-618
Doi: 10.1007/s00405-021-06676-x
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Andrianakis Alexandros
- Tomazic Peter Valentin
- Co-Autor*innen der Med Uni Graz
- Holzmeister Clemens
- Kiss Peter
- Koiner-Graupp Matthias
- Moser Ulrich Christian
- Wolf Axel
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- Abstract:
- PURPOSE: We aimed to investigate the effect of interval length and total count of intratympanic steroid (ITS) injections in salvage treatment of patients with idiopathic sudden sensorineural hearing loss (ISSNHL). METHODS: This retrospective case-control study included 64 patients with ISSNHL, who were treated with ITS injections as salvage therapy at a tertiary referral centre. From September 2019 to December 2020, 32 patients received up to four injections every 2-4 days (revised-protocol group). These patients were 1:1 matched to patients, who received up to three injections at 1-week intervals between January 2014 and August 2019 (initial-protocol group). Hearing outcomes of the two groups were compared. RESULTS: Both ITS salvage treatment protocols resulted in a statistically significant hearing improvement (p < 0.05). The initial-protocol declined hearing thresholds by 12 ± 11.7 dB (p < 0.001, d = 1, P = 99%). Mean hearing function was improved by 13.4 ± 19.1 dB in the revised-protocol group [p < 0.001, d = 0.7, P = 98%]. A clinically significant hearing improvement (> 10 dB) was seen in 18 patients (58.1%) in the initial-protocol group and in 14 patients (41.9%) in the revised-protocol group. A comparison of the hearing outcomes between protocol groups revealed no statistically significant differences (p > 0.05). CONCLUSION: These results indicate that a shorter injection interval does not lead to better hearing outcomes in ITS salvage treatment for ISSNHL. Moreover, fewer ITS injections may reduce costs, physical/mental stress of the patients and lower the risk of persistent tympanic perforations.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenal Cortex Hormones - therapeutic use
- Audiometry, Pure-Tone - administration & dosage
- Case-Control Studies - administration & dosage
- Dexamethasone - therapeutic use
- Glucocorticoids - therapeutic use
- Hearing Loss, Sensorineural - diagnosis, drug therapy
- Hearing Loss, Sudden - drug therapy
- Humans - administration & dosage
- Injection, Intratympanic - administration & dosage
- Retrospective Studies - administration & dosage
- Salvage Therapy - administration & dosage
- Treatment Outcome - administration & dosage
- Find related publications in this database (Keywords)
- Idiopathic sudden sensorineural hearing loss
- Salvage treatment
- Intratympanic steroid injection
- Interval
- Injection count